Author: Dr. Vikram Chauhan

February 15, 2023

Ayurvedic Perspective of Glanzmann Thrombasthenia – Platelet Disorders

ABSTRACT

Glanzmann Thrombasthenia is a bleeding syndrome type of rare autosomal recessive and characterised by platelet aggregation. GT is associated with clinical variability: some of them mild bruising but sometimes it occurred large blood vessels haemorrhage. Haematuria and gastrointestinal bleeding are less common but some of the characteristic sites of the bleeding are purpura, epistasis, gingival haemorrhage etc. In most cases, bleeding symptoms present afterlife but GT is diagnosed in later life. In the modern system of medicine full cure for treating this disease is not available; they, at last, transfuse platelets when no other option is left. This is not the proper way to treat any disease because after some time the platelets count decreased again. Ayurveda has many herbs indicating bleeding disorders that will definitely increase platelet count in a restorative way.

INTRODUCTION

Platelets are a very important component in stopping any kind of bleeding as in the case of hemostasis. In Hemostasis damaged sub endothelium releases adhesive proteins and fibrinogen which are attached to the site of injury with platelets and form a platelet plug. Platelets provide a surface for the attachment of coagulation factors. Then this will activate platelets to form a thrombus. Any kind of defect in this mechanism or process can cause bleeding disorders.

Glanzmann first described this in the year 1918 and called it “hereditary hemorrhagic thrombasthenia”. Its main characteristic features for diagnosis are prolonged bleeding time, clumped platelets and the appearance of platelets on a peripheral blood smear.

GLANZMANN THROMBASTHENIA

DIFFERENTIAL DIAGNOSIS

Platelet aggregation defects which are mainly due to adenosine diphosphate (ADP) or collagen can mimic Glanzmann thrombasthenia.  But GT has one specific feature of clot retraction. It is also sometimes misdiagnosed as Bernard- souler syndrome and vonwillebrand disease due to the involvement of platelet aggregation in both

AETIOLOGY

Megakaryocytes are present in the bone marrow and on maturity, they liberate large no. of platelets into the blood. In GT platelets can’t be aggregated in response to natural agonists while they are present in their normal shape. The genes which are defected in this disease are present on chromosome 17 of DNA. This is an autosomal recessive condition which means it occurs only if both parents are having this disease

SYMPTOMS OF GLANZMANN DISEASE

  1. Nose bleeding(Epistasis)
  2. Bruising easily
  3. Bleeding gums
  4. Heavy menstrual bleeding
  5. Bleeding during or after surgery
  6. Mucocutaneous bleeding

DIAGNOSIS

The clinical manifestation of some diseases is the same sometimes as in the case of  GT and other cases of platelet aggregation. The main diagnostic test for GT are:

  1. Normal platelet count
  2. Bleeding time
  3. Light transmission aggregometry
  4. Platelet function analyser
  5. Flow cytometry
  6. Mutation analysis

AYURVEDIC VIEW

In Ayurveda the body depends on anna(food) and other four factors namely vat, pitta, kapha and rakta . The rakta is considered to be the most important in it because any type of injury internal or external or any coagulation disorder leads to morbidity or mortality. This Glanzman thrombasthenia can be correlated with the rakta pitta it is said to be mahavega or mahagada by acharya charak mentioned in the classical medicinal textbooks of Ayurveda. In this disorder vitiation of pitta is the main cause of the disorder. Pitta is also called lohit pitta because it comes into touch with blood and can cause disease in the blood.

The treatment of bleeding disorder in Ayurveda can be done by shudha dravya varga which is highly composed of calcium carbonate, calcium sulphate, calcium fluoride etc. calcium helps in the coagulation of bleed; it is the important factor in the stoppage of blood. Thus shudha vargiya dravya helps in the coagulation of blood and pacifies the pitta and rakta dushti. Many kinds of animal origin, herbal origin and mineral origin are mentioned in Ayurveda for use as calcium supplements and help in raktapitta chikitsa.

Some of the shuddha vargiya dravya are as follows: Muktashukti(pearl), Shudha(lime), Godanti(gypsum) and pravala(coral) etc. All these are calcium compounds and are helpful in treating many diseases.

HERBAL REMEDIES BY PLANET AYURVEDA FOR TREATING GLANZMANN THROMBASTHENIA

Planet Ayurveda provides one of the most trusted herbal products and formulations for better treatment of diseases. The positive point of using these drugs is that they have no side effects and they are also Iso-certified herbal products which means these products are tested in the laboratory under various high technologies so that they can be trusted. Planet Ayurveda products do not contain any additives, flavours or preservatives which makes them more trustworthy.

Herbal Remedies for Glanzmanns Thrombasthenia

1. IMMUNE BOOSTER

It consists of many useful ingredients i.e it is used in treating Glanzmann thrombasthenia the main ingredients in it are Grape seed(Vitis vinifera std. ext.), Go-Piyush(Bovine colostrums std. ext.), Bhumi amla(Phyllanthus niruri std. ext.) and Amalaki(Emblica officinalis). In bleeding disorders like Glanzman thrombasthenia in this patient’s immunity is very weak and in this condition, if any other disease occurs it may be the worst condition for the patient. For protecting against any other disease and fighting with this disease.

Dosage: 2 capsules should be taken twice daily after meals

2. GILOY GHAN VATI

Guduchi(Tinospora cordifolia )has many beneficial properties in it which can be helpful in treating autoimmune diseases. It is also helpful in treating diseases like fever, diabetes, anaemia and jaundice etc. it is best to know treating raktapitta due to its rasa (taste) kashaya (astringent) is helpful in stopping the blood. It is also known to be balya(improves strength), dahahara (relieves burning sensation), vayasthapana (anti ageing) etc.

Dosage: 2 tablets should be taken daily two times

3. KUMAR KALYAN RAS

Its main ingredients are Ras sindura (formulation of pure mercury), Shudhha Mukta bhasma (purified pearl), Shuddha Swarna bhasma(purified gold) and Shuddha Loh bhasma (purified iron)etc. As discussed above ayurvedic medicine also mentioned the herbs made up through mineral sources also benefitting in many diseases like bleeding disorders, digestive disorders, cold and cough also they provide immune boosting through their actions.

Dosage: 1 tablet to be chewed daily two times

4. SUVARNA BASANT MALTI RAS

The main ingredients of this formulation are Swarna bhasma (purified gold), Mukta bhasma (pure pearl), Maricha (Piper nigrum) and Gandhak (pure sulphur)etc. This contains zinc and from research, it is stated that it can be helpful in the formation of RBC i.e the reason it can be used in the patient of Raktapitta. This formulation can be given in treating diseases like fever, cold and cough, asthma etc.

Dosage: 1 tablet to be chewed daily after meals two times

5. GREEN ESSENTIALS

It is given to patients for increasing immunity. It has many useful ingredients in it like Grape seed (Vitis Vinifera), Wheatgrass (Triticulum Aestivum), and Spirulina (Spirulina Platensis), Green tea (Camellia Sinensis) and Amla (Embllica Officinalis). The green herbs contain chlorophyll which plays a critical role in increasing the blood oxygen as we know the brain and every tissue works properly if oxygen is sufficiently present.

Dosage: One capsule should be given to the patient twice daily after meals

6. PUNARNAVA MANDUR

This formulation is made up of some beneficial ingredients some of them are listed: Punarnava (Boerhaavia diffusa ), Shunti (Zingiber officinale), Pipali (Piper longum) and Chavya (Piper chaba) etc. It is a very effective iron supplement which is mentioned in Ayurveda Samhitas. The principal ingredient is punarnava which is very effective as an anti-inflammatory, blood purifier and hematinic activities(an agent that tends to increase the production of red cell formation so that increases haemoglobin)

Dosage: 2 tablets twice daily after meals

7. SPIRULINA CAPSULES

Spirulina (Spirulina platensis) capsules are highly recommended sources to increase vitamins, minerals and ions. It is a very wonderful herb for maintaining good health. Spirulina is very rich in specific proteins which are superior to other forms of proteins obtained from plants. It contains essential 22 amino acids which even some legumes are not able to provide. Spirulina therapeutic indications: allergic conditions, cholesterol level maintenance, anti-inflammatory properties and antioxidant properties etc.

Dosage: 2 capsules twice daily after meals

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040 Or Check Website – www.PlanetAyurveda.com

CONCLUSION

In the present era, we will know about many diseases which can not be treated by allopathic medicine and that are not well described in them. In the modern system of medicine whenever they do not find any particular symptoms or particular diagnostic features they get confused.  On another side, ayurvedic medicine is recognised with great results in these diseases. Ayurvedic medicine is nowadays present with evidence-based approaches that are scientifically proven. In Ayurveda, most of the diseases occur due to variations of Vata, pitta and Kapha which are called Doshas. In this disease pitta dosha is imbalanced and to maintain it different herbs can be used which are mentioned in the medicinal textbooks of Ayurveda and they are able to treat well.

Continue Reading

February 15, 2023

Masticatory Muscle Myositis (MMM) Treatment By Ayurveda

Abstract

Autoimmune disorders are the disorders when the immune system of the body identifies the own muscle/tissue/organ as foreign and attacks them. Then the functions of the targeted organ gets hampered and it results in the altered structure of the organ affected. Masticatory muscle myositis in dogs is an autoimmune inflammatory condition that affects the chewing muscles of the dogs and leads to swelling and pain in the same. In the text below, we shall look into details of the disease. We shall also look at its management in the contemporary veterinary science and in the traditional Indian medicinal system of Ayurveda. Let’s get started!!

Masticatory Muscle Myositis (MMM)

Introduction

Masticatory muscle myositis (MMM) is an autoimmune and inflammatory disease in dogs affecting the muscles of the jaw. Signs include swelling of the jaw muscles and pain on opening the mouth. In chronic MMM there is atrophy of the jaw muscles, and scarring of the masticatory muscles due to fibrosis may result in inability to open the mouth (trismus). The condition is also known as eosinophilic myositis or atrophic myositis. This results when the immune system attacks the masticatory muscles of the dogs. The disease can  occur in any breed and can equally affect males and females. The average age of dogs with MMM is 3 years. Further in this text, we shall look into the causes, clinical features, ayurvedic aspect and management of masticatory muscle myositis in detail. Let’s discuss !!

Causes of Masticatory Muscle Myositis (MMM)

  • The main cause is autoimmune disease that some dogs may be predisposed to immune mediated disorders. Masticatory muscle myositis (MMM) is one of such conditions.
  • Other suspected things that trigger the occurrence of MMM include vaccinations, various allergens, stress, medications, environmental toxins, bacterial/viral infections.

Commonly Affected Breeds

  • Doberman Pinschers
  • German Shepherds
  • Golden Retrievers
  • Large breed dogs
  • Weimaraners
  • Cavalier King Charles Spaniels
  • Rottweilers

Signs and Symptoms

  • Swollen masticatory muscles
  • Painful opening of the mouth
  • Inability to eat and chew
  • Drooling saliva
  • Exophthalmos (protrusion of the eyeball)
  • Red eyes
  • Protrusion of the third eyelid
  • Lethargy

Investigations

  • Clinical features such as inability to open the mouth, troublesome/problematic eating, swollen muscles that facilitate chewing and the unbearable pain helps in making the diagnosis.
  • Blood work helps diagnose masticatory muscle myositis.
  • Muscle biopsy helps in making the diagnosis confirmatory and determine the intensity of inflammation and the stage of fibrosis as the deterioration of muscle tissue precedes.

Management of Masticatory Muscle Myositis (MMM)

  • The management scenario is based on the usage of an immune-suppressive dose of corticosteroid medication.
  • Early management of the condition with corticosteroid offers a chance of remission.
  • The dosage of the corticosteroid can be tapered down as the condition of the dog stabilises. The certain side effects of prednisone, the most commonly used drug include excessive thirst, excessive appetite and increased urination despite increased intake of water.
  • Pain medications are used to relieve pain associated with masticatory muscle myositis.

Ayurvedic Aspect and Management of Masticatory Muscle Myositis (MMM)

Ayurveda is an Indian traditional system of Ayurveda that has been serving mankind since ancient times. Ayurveda has two objectives – treating the diseases and keeping/maintaining the health of healthy people. Ayurveda is a vast science that helps in various health concerns from acute to chronic and mild to severe.

The direct correlation of the ayurvedic veterinary is not found but some ayurveda practitioners with their expertise in the ayurvedic veterinary have written articles and released textbooks which are full of knowledge of ayurvedic veterinary. 

When the management of masticatory muscle myositis is considered, then the main things that come to the light is that the basic things that make the human structure and animal structure are the same as they both belong to mammals. Therefore, some similarities are common. Hence the management depends on the lines of kapha and pitta dosha vitiation.

Medicines such as guduchi kwath, sanjivani vati, panchkol churna, amritarishta, pippalyasavam, mahatikta ghrita, rasa sindoor, shilajatu rasayana etc are effective in the management of masticatory muscle myositis.

Herbal Remedies by Planet Ayurveda for Masticatory Muscle Myositis (MMM)

Planet Ayurveda is an ayurvedic unit and an eminent US-FDA and an ISO 9001:2015 certified company. Planet Ayurveda manufactures the best ayurvedic formulations based on the reference given in the ayurvedic pharmacopoeia and other classical texts. The formulations are available in various forms such as vati (tablets), capsules, lehya (jams), asava arishta (syrups) and churna (powder). The products of Planet Ayurveda are free of contaminants and adulterants. Planet Ayurveda does not use any sort of chemicals, sweet enhancers, colours and other synthetic things to the medicines. Planet Ayurveda extends its wide range of products that are very unique and effective in a number of conditions. Planet Ayurveda presents its products that are helpful in overcoming the condition of masticatory muscle myositis.

Products that are helpful in the Management of Masticatory Muscle Myositis (MMM) are as follows

  1. YOGRAJ GUGGUL
  2. JOINT AID PLUS
  3. BOSWELLIA CURCUMIN
  4. BRAHMI CAPSULES
  5. CORAL CALCIUM COMPLEX
Herbal Remedies For Masticatory Muscle Myositis (MMM)
Herbal Remedies For Masticatory Muscle Myositis (MMM)

Product Description

1. YOGRAJ GUGGUL

Yograj Guggul is a classical ayurvedic medicine that is effective in the disorders related to the musculoskeletal system. The preparation contains a number of herbs such as amalaki (Emblica officinalis), guggul (Commiphora mukul), vidang (Embelia ribes), ela (Elettaria cardamomum), gokshur (Tribulus terrestris),  dalchini (Cinnamomum zeylanica), saindhav lavan (rock salt), shunthi (Zingiber officinale), dhania (Coriandrum sativum) etc. All these herbs are known to manage the musculoskeletal disorders, alleviating inflammation and pain and pacifying the kapha dosha. Hence, with these exotic properties of kapha pacification, Yograj Guggul helps in managing the condition of masticatory muscle myositis. 

Dosage: Three tablets twice daily

2. JOINT AID PLUS

Joint Aid Plus is a patent product of Planet Ayurveda which is composed of the herbs that are known to be beneficial for the muscles and bones. The ingredients of the formulation are nirgundi (Vitex negundo), shallaki (Boswellia serrata), guggul (Commiphora mukul), sonth (Zingiber officinale) and ashwagandha (Withania somnifera). Joint Aid Plus helps in alleviating the pain related to the inflamed masticatory muscle. Guggul and shallaki alleviates the inflammation through their anti-inflammatory properties and ashwagandha provides strength to the muscle and hence promotes the activity whereas nirgundi and sonth heals the damage of the muscle and alleviates the pain. With immense properties of these herbs, Joint Aid Plus helps in managing masticatory muscle myositis maximally.

Dosage: Two capsules twice daily

3. BOSWELLIA CURCUMIN

Boswellia Curcumin capsules are a very special and unique formulation prepared by Planet Ayurveda. It is composed of Shallaki (Boswellia serrata) and haridra (Curcuma longa). Both the herbs have analgesic and antiinflammatory activity which helps in the alleviation of inflammation and pain associated with masticatory muscle myositis. It promotes the healing of the affected muscles and also provides strength to the same. Henceforth, Boswellia Curcumin is indeed a very crucial formulation that works wonderfully in the management of masticatory muscle myositis (MMM).

Dosage: Two capsules twice daily

4. BRAHMI CAPSULES

Brahmi capsules of Planet Ayurveda are very helpful in a number of diseased conditions. Brahmi capsules of Planet Ayurveda are filled with the pure herbal extract of the herb brahmi (Bacopa monnieri). Brahmi is a potent analgesic and anti-inflammatory. Brahmi relieves the lethargy and provides a relaxed and good mood by its mind calming properties. With its analgesic properties, brahmi alleviates the pain and elevates the mood of the dog suffering from masticatory muscle myositis. Therefore, Brahmi capsules are such a unique and healthy capsule that helps in the mentioned condition.

Dosage: Two capsules twice daily

5. CORAL CALCIUM COMPLEX

Coral Calcium Complex is a mineral based supplement prepared by Planet Ayurveda. Coral calcium complex is composed of ayurvedic formulation and praval pishti (Coral), akik pishti (Agate), kamdudha ras, jawar mohra pishti, mukta pishti (Pearl) and guduchi (Tinospora cordifolia).  All these ingredients of coral calcium complex are vital that keeps the essential minerals that are needed for the working of the musculoskeletal system. Coral Calcium Complex provides all the nutrition to the muscle and helps in the healing of the same and helps in managing masticatory muscle myositis.

Dosage:  Two capsules twice daily

CONTACT PLANET AYURVEDA TO PROVIDE YOU THE COSTING / ORDERING AND DELIVERY INFORMATION AT – COSTING.PLANETAYURVEDA@GMAIL.COM OR CALL AT +91-172-5214040 OR CHECK WEBSITE – WWW.PLANETAYURVEDA.COM

Conclusion

Masticatory muscle myositis is a condition that makes the life of a dog pitiful and miserable. And the outlook of the affected patient depends on the extent of inflammation in the muscles and the response of the patient to the given treatment. If the management is started within a short period of time when the condition is not so severe the chances of the recovery stays high and the patient dog usually regains the normal function of the masticatory muscle. Though in certain cases the scar tissue after the fibrosis stays and results in causing certain permanent concerns. There are chances of relapse. But the above-mentioned herbal medicines of Planet Ayurveda makes the condition go away and the chances of recurrence also diminishes. Masticatory muscle myositis is thus an important condition that must be acknowledged as soon as possible and the management of the same should start from the very beginning. In the last, masticatory muscle myositis stays unknown for a long time but as soon as it becomes obvious then the ayurvedic herbal management should be done due to its positive and side-effects free approach.

Continue Reading

Click the CROSS button to close