Tag: Osteogenesis Imperfecta Treatment

OSTEOGENESIS IMPERFECTA – CAUSES, SYMPTOMS AND AYURVEDIC TREATMENT

Abstract

Osteogenesis imperfecta is a genetic bone disorder which exists by birth. A baby born with osteogenesis imperfecta has fragile or soft bones that can fracture easily. The clinical features vary from patient to patient. It is a long lasting hereditary disorder that leads to easy break of the bone oftenly without any injury or fall. So today we will read about osteogenesis imperfecta in brief.

Osteogenesis Imperfecta

Introduction

Osteogenesis imperfecta is also called brittle bone disease. It is a hereditary disorder which inhibits the formation of strong bones. It is developed due to abnormal synthesis of type I collagen. Osteogenesis imperfecta is characterized due to declined bone density and is prone to bone fracture. Other manifestations, such as blue sclerae, short stature, dentinogenesis imperfecta and deafness in adult phase. There are various types of osteogenesis imperfecta and the issues it leads to are varied.

Causes

It is caused by gene mutation. Gene holds information which is passed to the baby by parents. Due to gene mutation collagen is not produced enough or does not function properly that leads to brittle bone disease.

Symptoms

  • Curved spine
  • Bowing or malformed of the long bone
  • Weak muscles
  • Bruises in skin easily
  • Small stature
  • Loose joints
  • Sclera looks purple, gray or blue
  • Face look like triangle shaped
  • Barrel shaped rib
  • Hearing loss
  • Compression or collapse of vertebrae
  • Teeth not aligned well
  • Discolored or brittle teeth
  • Breathing problems
  • Excessive fatigue
  • Short height
  • Broken bones
  • Joint contractures

Diagnose

  • Physical examination
  • Genetic testing
  • Urine test
  • Blood test
  • X-ray
  • Bone density test

Treatment

There is no treatment for this condition only we can manage the sign and symptoms by following criteria:-

  • Physical therapy:- It provides strength and movement to the body.
  • Casts and splints for fractured bones
  • Occupational therapy
  • Dental therapy for brittle teeth
  • Braces for the weak knees, wrists, ankles and legs
  • Medicine to provide strength to bone
  • Surgery

Ayurvedic overview

In Ayurveda, we can correlate this disease with sahaja vyadhi (Genetic disorder) along with vitiated vata dosha. Sahaja vyadhi is developed by abnormality in sperm and ovum which pass the mutated genes in the new progeny and leads to genetic disorder. The vitiation of vata dosha afflicts the body with various disorders relating to their location and functions and takes away life shortly. Causative factors like rough, little, cold and light food, excessive coitus, faulty therapeutic treatments, excessive jumping or walking, emaciation, fear, suppresses natural urges etc aggravated vata dosha and filling up the vacant channels in the body produces various disorders pertaining to the entire body or one of the parts and produce symptoms like contractures, stiffness in joints, tearing in bones and joints, horripilation, stiffness in hands, back and head, insomnia, tearing piercing pain etc which are closely resemble with the symptoms of brittle bone disease.

Treatment

There is no treatment for this disease. We can only manage the signs and symptoms and increase the quality of life of the patient instead of cure. In Ayurveda, firstly we have to avoid causative factors which lead to aggravate vata dosha and second thing we have to balance the vata dosha. Planet Ayurveda gives herbal remedies for this disease which is described below.

Herbal remedies for Osteogenesis imperfecta by Planet Ayurveda

Planet Ayurveda provides various types of Ayurvedic medicines for the management of various types of disorders. The company follows all the concepts of Ayurveda to prepare the medications which are described in the Ancient Samhita. All the herbal remedies are GMP certified and are very effective for the human body. Herbs which are used to prepare medicine are high in efficacy, pure and natural. All the medicines are purely vegetarian with no side effects and are free from any preservatives, yeast, additives and other chemicals. Planet Ayurveda provides herbal remedies for osteogenesis imperfecta for the management of the condition instead of treatment or cure.

  1. Lakshadi guggul
  2. Bone support
  3. Cissus power capsules
  4. Boswellia+Curcumin
  5. Gandhak rasayan
  6. Arjun ghrit

PRODUCT DESCRIPTION

1. Lakshadi guggul

It is a herbal tablet containing laksha (Laccifer lacca), arjuna (Terminalia arjuna), ashwagandha (Withania somnifera), shuddha guggulu (Commiphora mukul), etc. It is bitter in taste and hot in effect. It balances Vata, Pitta and Kapha dosha. It is sharp, unctuous, light, dry and sticky in nature. It has mineral matter like calcium, silicon dioxide, magnesium, iron and a volatile oil. It is very effective medicine for different types of joint problems like rheumatoid arthritis, gout and osteoarthritis. It helps in reducing pain, tenderness and swelling of the joints. It is a mild sedative which can help in good sleep. It has a tonic effect in the nervous system. It regulates all the vital functions of the body. It prevents the soft bone from fracture. It treats emaciation, low backache, arthritis, impotency, insomnia and hypertension. It reduces all types of weakness and fatigue.

Dose:– 2 Tablet twice daily

2. Bone support

It is a poly herbal capsule containing shudh laksha (Laccifer lacca), hadjod (Cissus quadrangularis), arjun (Terminalia arjuna), mukta (Compound of pearl calcium), etc. It pacifies all the vitiated doshas (Vata, pitta and kapha). It reduces swelling, pain and illness associated with bone fracture. It contains luteolin and beta-sitosterol flavonoids that are responsible for anti-inflammatory action. It is indicated in obesity, diabetes, infertility, piles, arthritis, etc. It helps in protecting the liver also.

Dose:- 1 Capsule twice daily

3. Cissus power capsules

It is a single herbal capsule containing hadjod (Cissus quadrangularis). It is sweet and pungent in taste. It balances Vata and Kapha dosha. It is very effective in bone fracture because it has sandhaniya guna (Promote union of fracture part). It improves metabolism. It prevents accumulation of lipid and fats and declines the triglycerides level that helps in reducing weight. It is an effective wound healer. It acts as anti inflammatory, analgesic, anti diabetic, anti malarial, etc. It is used to treat osteoporosis, gout, rheumatoid arthritis, upset stomach, seizures, menstrual pain, and high cholesterol.

Dose:- 1 twice daily

4. Boswellia+Curcumin

It is a poly herbal capsule containing shallaki (Boswellia serrata) and haridra (Curcuma longa). It is bitter and pungent in taste. It is light, dry and hot in effect. It is an astringent, anti diabetic, anti bacterial, anti allergic, diuretic, carminative, digestive, and antioxidant. It contains carbohydrates, minerals, protein, vitamin A, and volatile oils. It stops the tumors of the colon and skin due to its anticancer property. It is very effective medicine for wounds, sprains and inflamed joints. It applies on bruises and cuts due to its excellent antibiotic property. It helps to improve the complexion of the skin. It stops the cytokines to prevent inflammation.

Dose:- 1 Capsule twice daily

5. Gandhak rasayan

It is a herbal tablet containing shuddha gandhak (Purified sulphur). It possesses antiviral, antimicrobial and antibacterial properties. It is a potent antibiotic medicine. It is very effective in skin disorders, pruritus, chronic fever, malabsorption, bleeding disorders, oligospermia, diarrhea and urinary tract infection. It is a powerful anti-aging medicine that promotes immunity and skin complexion. It is a demulcent, anthelmintic, anti inflammatory, antipruritics, anti-leprosy, antipyretic, antioxidant, aphrodisiac, analgesic and a great blood purifier. It boosts immunity in the body.

Dose:- 2 Tablet twice daily

6. Arjun ghrit

It is a product described in the classical textbook of ayurveda containing arjuna (Terminalia arjuna), ghee, etc. It is astringent in taste. It is dry, cold and light in effect. It pacifies vata, kapha and pitta dosha. It contains calcium, aluminium, magnesium, arjunine, arjunetine and lactone. It is very effective in cardiac disorders. It helps in raised lipid profile, obesity, hypertension and hyperglycemia. It is an antipyretic, astringent, healer of wounds, antifungal and antibacterial. It is considered as a cardio-protective element. It promotes vitality and general health in heart patients. It treats chronic fever, edema, asthma, obesity, cough and many other skin diseases. It helps bones to regain strength after fractures. It is a good appetizer and promoter of memory, intelligence, complexion, glow and amiability of features and principle of strength. It is described as a vitalizing and rejuvenating agent. It is also laxative in nature.

Dose:- Half Tsp twice daily with warm milk or water

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040

Conclusion

In this article we read about brittle bone disease which is a genetic disorder caused by gene mutation in which collagen does not work well or is not produced enough which can easily cause fracture of bones. In Ayurveda, we relate this condition with sahaja vyadhi along with vitiated vata dosha. There is no treatment for this disease but we can manage this condition to reduce signs and symptoms and delay the progression of disease and improve the quality of life. Herbal remedies like arjun ghrit, gandhak rasayan, lakshadi guggul, bone support etc are very effective in this condition.

Ayurvedic Treatment for Osteogenesis Imperfecta / Brittle Bone Disease

ABSTRACT

Osteogenesis Imperfecta is an inherited disorder of Type I collagen. It is a rare disorder. It is also called Brittle Bone Disease because bones get easily fractured. Due to the lack of type I collagen there is difficulty in making connective tissue that makes bones. Collagen provides mechanical strength to bones. As a result of genetic defects, there is inhibition in the production of collagen that results in Osteogenesis imperfecta. Osteogenesis Imperfecta is characterized by weak bones which can break easily. Let’s discuss it in detail!

Osteogenesis Imperfecta/Brittle Bone Disease

INTRODUCTION

Osteogenesis imperfecta is an inherited disorder that means imperfect bone formation. It is grouped under heterogeneous genetic disorders. A person with osteogenesis imperfecta has more risk of multiple fractures throughout their lifetime. Infants born with OI have difficulty in making connective tissue due to a lack of type I collagen. Based on patterns of inheritance and clinical symptoms, it is divided into 4 types. Osteogenesis imperfecta Type I shows mild or late fractures whereas Osteogenesis Type II shows perinatal fractures which are fatal. A person with Osteogenesis Type III shows bone deformity with fractures (severe) and in Type IV bones are brittle and short stature can be seen. Out of these Osteogenesis imperfecta Type I is the most commonest type. Management of Osteogenesis imperfecta involves strengthening of bones and pain management.

CAUSES

Genetic mutation

Mutations in the genes coding for pro alpha 1 collagen chain located on chromosome 17 and pro alpha 2 collagen chains located on chromosome 7.

SYMPTOMS

  • Brittle bones/Bone fractures
  • Bone deformity
  • Scoliosis
  • Brittle teeth
  • Deformed teeth (Dentinogenesis imperfecta)
  • Hearing loss
  • Short stature
  • Blue sclerae (Bluish discoloration of the white part of the eye)

DIAGNOSIS

  • Genetic testing: Done to detect OI before birth
  • Blood test
  • Bone density test

AYURVEDIC OVERVIEW

According to Ayurveda, Osteogenesis imperfecta is caused due to Bija Dushti (abnormal sperm and ovum). It comes under Sahaj or Kulaj Roga(Hereditary disorder). Bija dushti along with the uterine factors, diet, and lifestyle of the mother is responsible for the vitiation of Vata dosha. This vitiated vata is responsible for asthi kshaya (Decrease in bone mass) causing abnormality in bones and leading to weak bones. In OI bones are very weak and can get broken very easily. Vitiated Vata also results in Kubja (Scoliosis), hearing loss, bluish discoloration of eyes, weaker and poor developing teeth. In Ayurveda, Osteogenesis imperfecta is managed with herbs that help in pacifying Vata dosha and strengthens bones to avoid fractures.

TREATMENT

Management of Osteogenesis imperfecta involves the use of Rasayan (Rejuvenating medicines), Balya aushadi (Strengthening herbs) and abhyanga (Massage) in order to strengthen bones.

Rasayan

It includes Gnadhak Rasayan, Mukta shukti, Makardhwaja etc.

Balya aushadi

Shatavari (Asparagus racemosus), Ashwagandha (Withania somnifera), Musli (Chlorophytum borivilianum), Hadjod (Cissus quadrangularis) etc.

Abhyanga (Massage)

Oil massage should be done with Dhanwantharam thailam, Chakra thailam, Ksheerabala thailam etc.

Herbal Remedy for Osteogenesis Imperfecta by Planet Ayurveda

Planet Ayurveda provides the best combination of effective herbal remedies for the management of Osteogenesis imperfecta. For natural and herbal treatment always look for natural products which contain pure extracts and are formulated under GMP guidelines. Planet Ayurveda products are scientific and certified. They are free from any chemicals, additives, and preservatives. Planet Ayurveda products are formulated by MD Doctors and are 100% natural, pure, and free from side effects. Planet Ayurveda offers the following herbal remedies for the management of Osteogenesis imperfecta.

PRODUCTS List

  1. Lakshadi Guggul
  2. Bone Support
  3. Cissus Power
  4. Boswellia Curcumin
  5. Gandhak Rasayan
  6. Arjun Ghrit

PRODUCT DESCRIPTION

1. Lakshadi Guggul

Lakshado guggul is a herbal formulation that contains Laksha (Laccifer lacca), Asthisamharaka (Cissus quadrangularis), Arjuna (Terminalia arjuna), Ashwagandha (Withania somnifera) and many other herbs. Laksha is Kapha and Pitta Shamak (balances Kapha and Pitta dosha). It is exclusively used in chest injuries. It is helpful in preventing bone degeneration and promotes the healing of bone fractures. Guggul balances all three doshas and reduces bone pain.

Dosage: 1-2 tablets twice or thrice daily with lukewarm water.

2. Bone Support

Bone support is a wonderful formulation that contains Shudh Laksha (Laccifer lacca), Suhanjana beej (Moringa oleifera), Hadjod (Cissus quadrangularis), Arjun (Terminalia arjuna) and various other herbs. Suhanjana beej in this formulation is a rich source of calcium. This herbal formulation helps in the formation of new bone cells and heals bone fractures. Hadjod is responsible for restoring bone mass and promoting collagen formation.

Dosage: 1 capsule twice daily, after meals with plain water.

3. Cissus Power Capsule

Cissus Power capsule is a herbal formulation that contains Hadjod (Cissus quadrangularis). Hadjod is known for its Bhagan Sandhanakara (healing fractures), and balya (strengthening) properties. It is vata and kapha shamak (Pacifies Vata and Kapha) and ushna (hot) in potency. It also improves appetite, resolves indigestion and regulates bowel movements.

Dosage: 1-2 capsules twice daily, with plain water after meals.

4. Boswellia Curcumin

Boswellia curcumin is a herbal formulation that contains Shallaki (Boswellia serrata) and Curcumin (Curcuma longa). Curcumin has anti-inflammatory and analgesic properties. This extract helps in pacifying Vata dosha. Shalaki balances Kapha and Pitta.

Dosage: 1 capsule twice daily, after meals with plain water.

5. Gandhak Rasayan

Gandhak Rasayan is a herbal formulation that contains Shuddha Gandhak (Purified sulphur). It acts as a rasayan and helps in the formation of healthy bone cells. It provides relief from bone pain and brittle bones associated with OI. It is used in a wide range of bone problems.

Dosage: 1-2 tablets twice or thrice daily with lukewarm water.

6. Arjun Ghrit

Arjun Ghrit is an Ayurvedic formulation that contains Arjuna swarasa (Terminalia arjuna juice), Arjuna Kalka (Terminalia arjuna paste) and cow ghee. Arjuna is a good source of calcium. According to Acharya Chakrapanidutta, arjuna helps in healing fractures. Arjuna ghrita is also responsible for strengthening heart muscles and improving blood circulation to bones.

Dosage: ½ tablespoon twice with warm milk or water.

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 9915-593-604

CONCLUSION

Osteogenesis imperfecta is a rare condition that causes weak bones as a result of genetic mutations. Type I collagen which is a major component of bone is produced in poor quality resulting in fragile bones that break easily. In Ayurveda, it is co-related with vata imbalance that results in Asthi kshaya (Decrease in bone mass). Ayurveda takes a holistic approach with herbs that help in balancing Vata and strengthens bones in order to manage Osteogenesis imperfecta.