Tag: Natural Treatment for SAVI

Sting Associated Vasculopathy Infancy Dependent Treatment in Ayurveda

Abstract

Sting-associated vasculopathy is an uncommon disorder that causes aberrant inflammation and skin and interstitial lung disease lesions. It was originally found in 2014. Because of the gene mutation that results in it, it is a hereditary condition. High death rates are associated with its characteristic neonatal onset. Now, we discuss sting-associated vasculopathy in detail. The affected person experiences the Raynaud phenomenon, in which the affected area turns red with exposure to cold and stress and changes color from white to blue. It might also be required for amputation.

Sting Associated Vasculopathy, Infancy Dependent

Introduction

The hereditary disorder known as “sting-associated vasculopathy” causes aberrant inflammation throughout the body, with the skin, blood vessels, and lungs experiencing the most of the effects. It is an auto-inflammatory illness and a rare condition. It begins during infancy. Vasculopathy and interstitial lung disease are its primary characteristics.

Causes of SAVI

Genetic changes are the root cause of sting-associated vasculopathy. A mutation in the STING1 gene results in an overproduction of the inflammatory proteins that harm tissue and increase inflammation. This gene is important for producing the STING protein, which produces cytokines that cause inflammation.

Symptoms Of SAVI

  • Unhealing wound
  • Minimal fever
  • Joint rigidity
  • Muscle soreness
  • Dyspnea
  • Respiratory lesions
  • Enlarged lymph node
  • Failing to flourish
  • Coughing
  • Lungs with interstitial disease
  • Hypermobility
  • Skin blemishes can be found on the cheeks, nose, ears, fingers, and soles of the feet.
  • A fibrotic lung

Diagnosis Of SAVI

  • Chest X-rays
  • Magnetic resonance imaging
  • Blood culture
  • Lung biopsy
  • CT scan
  • Genetic testing

Treatment

This illness has no specific treatment. Management can only be supportive.

  • Corticosteroids
  • Biological agents
  • Immunosuppressant

Ayurvedic Aspect of Sting Associated Vasculopathy

In Ayurveda, we can correlate the sting-associated vasculopathy with onset in infancy with Bija dushti (Abnormal ovum and sperm).

According to Acharya Charaka: (च. शा. ३/१७)

This theory holds true for each and every srota (channel). Any Beeja Bhaga gene whose function is compromised by the doshas (Vata, Pitta, and Kapha) manifests as a sickness or disease. It falls under the heading of a hereditary disease called Sahaja or Kulaj roga. Genes, or bija bhaga avayava, are the fundamental building blocks of all living things. Genes contain the instructions needed to create, maintain, and pass genetic features to progeny in an organism. If the male and female are both bija damaged totally, neither can generate new offspring, but if just one is contaminated, the offspring will be defective. The bija bhaga avayava is where abnormal doshas (Vata, Pitta, and Kapha) enter, causing disease to develop there with symptoms like dyspnea, growth retardation, skin lesions, joint stiffness, and pulmonary diseases.

Treatment

Genetic or hereditary illnesses cannot be cured. There is no known cure for this illness. Only supportive care can be provided to control symptoms and halt the spread of the disease. The following list of herbal treatments for SAVI is provided by Planet Ayurveda as supportive management.

Some Herbal Remedies for Sting Associated Vasculopathy by Planet Ayurveda

Planet Ayurveda is a certified ayurvedic clinic, and the formulation of different types of remedies is performed here to provide relief from diseases. All formulations at Planet Ayurveda are made organically without the use of preservatives. These remedies are formulated under the guidance of MD Ayurvedic practitioners. Planet Ayurveda offers a variety of herbal products that have no negative effects for treating sting associated vasculopathy.

Product Lists

  1. BOSWELLIA CURCUMIN
  2. ARVINDASAV
  3. INFEE SYRUP
  4. MANJISHTHA CAPSULE

Product Description

1. Boswellia Curcumin

Boswellia curcumin is a multi-herbal capsule that includes haridra (Curcuma longa) and shallaki (Boswellia serrata). It has a spicy and bitter flavour. It harmonizes the body’s three doshas—Pitta, Kapha, and Vata. It is unctuous, dry, sticky, sharp, and light. It includes mineral stuff such as calcium, silicon dioxide, iron, volatile oil, and magnesium, as well as organic molecules and inorganic ions. For a variety of joint issues, including osteoarthritis, gout, and rheumatoid arthritis, it is a very helpful medication. It aids in lowering joint inflammation-related discomfort, soreness, and swelling.

Dosage: with plain water, after meals, take 1 capsule twice daily.

2. Arvindasav

Arvindasav is a multi-herbal formulation that is formulated by Planet Ayurveda by using herbs like arjun (Terminalia arjuna), khairati (Sida cordifolia), mulethi (Glycyrrhiza glabra), manjith (Rubia cordifolia), and some other herbs. It has an unctuous, rich, heavy, and cold effect. All three doshas—Vata, Pitta, and Kapha—are calmed by it. It is a drug that acts as an antipyretic, anti-inflammatory, and wound healer. It enhances the complexion, soothes eye issues, acts as an antacid, and is also a potent general tonic. Calcium, glucose, starch, vitamin B, and potassium are all present in it. It liquifies the mucus and helps in its smooth excitation. It is indicated for cough, asthma, bronchitis, and other chest conditions. It enhances voice quality, supports body weight, and counteracts excessive thirst and weariness. It stimulates the digestive system.

Dosage: after meals, with equal amounts of water (10 ml twice daily).

3. Infee Syrup

Infee is a multi-herbal syrup that is formulated with the help of yashtimadhu (Glycyrrhiza glabra) and guduchi (Tinospora cordifolia). It balances the kapha, pitta, and vata-vitiated doshas. Additionally, it has antipyretic, anti-inflammatory, and wound-healing properties. It is unctuous, spicy, astringent and bitter. Fatty acids, alkaloids, volatile oils, and glycosides are all present. It is prescribed for conditions like gout, rheumatoid arthritis, fever, dyspepsia, and urinary disorders. It contains rejuvenating, immunomodulating, and antioxidant effects. It helps reduce the level of uric acid.

Dosage: 5 drops in infants and 1/2 tsp with water.

4. Manjishtha Capsules

Manjistha capsules are a single herbal formulation that is formulated by Planet Ayurveda with the help of Manjistha (Rubia cordifolia). It is a blood purifier, detoxifier, hematopoietic system booster, and complexion enhancer. Additionally, it functions as an antibacterial, hemostatic, digestive, and carminative agent. It has uterine stimulant and anti-inflammatory effects. It has a hot, dry, and heavy effect while tasting bitter, astringent, and sweet. It calms down the kapha and pitta doshas. It is advised in cases of dysentery, persistent fever, diarrhea, and uterine and urinary infections. It helps with scars, acne and blemishes and also repairs the skin tissues that have been harmed or infected.

Dosage: after meals, with plain water, 1 capsule twice daily.

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 9915-593-604

Conclusion

Sting-associated vasculopathy is an uncommon disorder that causes aberrant inflammation and skin and interstitial lung disease lesions. It was originally found in 2014. Because of the gene mutation that results in it, it is a hereditary condition. It is an auto-inflammatory illness and a rare condition. It begins during infancy. Vasculopathy and interstitial lung disease are its primary characteristics. In Ayurveda, we can correlate the sting-associated vasculopathy with onset in infancy with Bija dushti (Abnormal ovum and sperm). On Planet Ayurveda, there are some herbal formulations that are used for the management of sting-associated vasculopathy without causing any side effects.

Sting Associated Vasculopathy of Infancy (Savi)- Treatment in Ayurveda

ABSTRACT

SAVI is a disorder or vasculopathy which begins during the infant period. It is a very rare inflammatory disease when there is inflammation throughout the body especially in skin, blood vessels and lungs. It manifests as systemic inflammation, interstitial lung disease and cutaneous infection. Patients present with recurrent cough, failure to thrive, skin scaling, poly arthritis, interstitial lung disease, and necrosis and auto amputation. SAVI is type1 interferon disorder caused due to mutations in STING1 stimulator of interferon gene protein. Patients carry heterogeneous substitutions in STING1. It is a life threatening condition because there is a gain of function mutations in STING1. Sting regulates various pathways such as functioning of proteins. Lung involvement leads to morbidity and mortality in sting associated vasculopathy. Chest CT and lung biopsy are the measures to diagnose this disorder during infancy. As it is a genetic disorder there is risk of another child being born with a similar problem. In this article we will discuss STING associated with vasculopathy of infancy, its cause, symptoms, diagnosis and its treatment according to classical Ayurveda texts.

SAVI-String Associated Vasculopathy Infancy

INTRODUCTION

SAVI is a genetic disorder which begins in neonates or infants causing systemic illness and vasculopathy of small vessels. Due to excessive inflammation in the body it leads to destruction of the body’s own cells and tissues. It is also known as auto inflammatory disease. Most patients have problems with blood vessels and tissues which affects blood circulation. There is particular damage to skin tissues of the face, nose, toes, fingers, etc. Skin lesions appear which develop into wounds. Skin problems may worsen during cold weather and cause skin discoloration. Sometimes it may involve the respiratory system which can be a life threatening condition (affects breathing pattern). The patient may have intermittent low grade fever and may affect lymph nodes. There is quite a therapeutic limitation of sting associated vasculopathy of infancy as supportive treatment can be done. The severity of disease depends on the number of gene mutations taking place. There is association of interferon genes protein characterized by skin and lung symptoms. There is over activation of type1 interferon pathway. STING is a transmembrane protein which plays an essential role to innate immunity against viral and bacterial pathogens.

CAUSES

As we know SAVI is a genetic disorder which onset during infancy and there is disturbance in one or more genes. It can be inherited disorder like autosomal dominant inheritance. There is a mutation in the STING1 gene. This gene helps in functioning of proteins and immune system responses. In this disorder beta interferons are produced which is a kind of protein that promotes inflammation. This inflammatory change leads to tissue damage and leads to development of signs and symptoms.

SYMPTOMS

The sign and symptom of this disease starts appearing during infancy. By growing age, symptoms may differ and they appear at any age. Some of symptoms of SAVI are as following

  • Skin lesions
  • Ulcers, necrosis (non- healing)
  • Skin discoloration ( purplish)
  • Low grade fever
  • Swollen lymph nodes
  • Finger/toe tips white or bluish
  • Interstitial lung disease
  • Pulmonary fibrosis
  • Difficulty in breathing
  • Joint stiffness
  • Muscle inflammation
  • Cardiovascular involvement
  • Esophageal reflux
  • Tachypnea
  • Anemic syndrome

DIAGNOSIS

The diagnosis for SAVI are as following

  • Clinical examination
  • Medical history
  • In Ayurveda darshan, prashan and sparshan is done. (inspection, history and examination)
  • CBC (Hb- decreased, ESR- raised)
  • Antenatal and postnatal examination
  • Genetic metabolic screening/ sequencing
  • Imaging like chest x- ray
  • Biopsy
  • Gene testing
  • Duplication analysis

MANAGEMENT

As we know it is a genetic disorder, no specific treatment is available. SAVI is a very challenging condition for managing so supportive treatment is done. Some of the measures are given as following

  • Corticosteroids
  • Immunosuppressant
  • Biologic agents
  • Somatic gene therapy

AYURVEDIC POINT OF VIEW REGARDING STING ASSOCIATED VASCULOPATHY IN INFANCY (SAVI)

Ayurveda is a traditional system of medicine which believes in natural herbs (aushadh), lifestyle activities (vihar) and dietary changes (aahar). In classics there is no particular correlation with sting associated vasculopathy of infancy but according to symptoms it can be related according to dosha predominance such as there is predominance of vata and kapha dosha. According to Acharya kashyap in vednaadhya (chapter related to different kinds of disorders in children) it can be related to its signs and symptoms. So, as Ayurveda believes in dosh, dhatu and mala this disease can be treated accordingly.

HERBAL REMEDIES FOR STING ASSOCIATED VASCULOPATHY OF INFANCY BY PLANET AYURVEDA

Planet Ayurveda is a well authorized and GMP, ISO certified manufacturing company. It has been spread throughout the world due to its purity in natural and herbal products. All the formulations prepared here are as discussed in our classical texts and under expert supervision. Products manufactured here are free from any preservative, color, starch, yeast, etc. The best combination of herbal medicines for Sting Associated Vasculopathy of Infancy (SAVI) by Planet Ayurveda are as following

Product List

  1. Boswellia Curcumin
  2. Arvindasav
  3. Syrup Infee
  4. Manjishtha Capsules

PRODUCT DESCRIPTION

1. Boswellia curcumin

It is a standardized capsule formulation prepared from the extract of shallaki (Boswellia serrata), haldi (Curcuma longa). These capsules have anti-inflammatory properties and reduce all types of pain. It has antioxidant properties and cures degenerative disorders. It plays an important role in the respiratory system such as in asthma.

Dosage- One capsule twice daily with plain water after meals.

2. Arvindasav

It is a syrup formulation from our ancient classical texts prepared from extract of kamal phool (Nelumbium speciosum), khus (Vetiveria zizanioides), gambhari (Gmelina arborea), etc. It promotes proper growth and development of children. It increases appetite, digestion and corrects recurrent respiratory infections. It corrects delayed milestones and rickets problems in infants. This syrup improves appetite, strength in children.

Dosage- Two tablespoons mixed with equal amounts of water taken twice daily after meals.

3. Syrup Infee

This is a syrup formulation prepared from extract of yastimadhu (Glycyrrhiza glabra), guduchi (Tinospora cordifolia), bibhitaki (Terminalia Billerica), etc. It acts as an immunomodulator and protects children from repeated infections. It boosts child immunity and helps ingrowth of the child. It protects children from recurrent respiratory and GI infections. It helps to strengthen weak children and children suffering from cough and bronchitis.

Dosage- Two tablespoons twice daily with plain water after meals.

4. Manjishtha capsules

It is standardized capsule formulation prepared from extract of manjishtha (Rubia cordifolia). It acts as a blood purifier, anti platelet, anti stress and calcium channel blocker. It is used to treat skin problems (skin rejuvenating, lightens if any spots) and has anticancer properties.

Dosage- One capsule twice daily with plain water after meals.

Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4030 (India), +91-172-521-4030 (Outside India) or Whatsapp at (+91) 9915-593-604

Conclusion

Sting associated vasculopathy is a very rare, genetic auto inflammatory disease which begins during the infant period. This disorder can affect a child’s life as it involves tissue damage of skin, vessels and pulmonary system. Here Planet Ayurveda gives the best combination of medicines for SAVI as they are prepared under expert’s supervision. For any severity you may concern the physician and team of planet Ayurveda is always there for any type of guidance.