Tag: Idiopathic thrombocytopenic purpura

Abstract

Idiopathic Thrombocytopenic Purpura (ITP),also known as Immune Thrombocytopenia is a auto-immune disorder characterized by isolated thrombocytopenia platelet count 100,000/ul without another identifiable cause .In ITP, autoantibodies destroy circulation platelets and may impair platelet production, increase the risk of bleeding Let us discuss more about this!

Introduction

Idiopathic Thrombocytopenic Purpura (ITP) also called Immune Thrombocytopenia -it is an autoimmune disorder where the immune system mistakenly attacks and destroys blood- clotting platelets. This results in easy bruising, bleeding gums, nose bleeds and pinpoint red dots on the skin, reddish-purple dots on the skin that look like a rash.Low level of the cells that help blood clot, also known as platelets, most often cause the bleeding.

Causes

• The system that protects your body from germs accidentally attacks your own platelets instead .
• In adults some infections can trigger ITP. these includes HIV, HEPATITIS and a stomach infection caused by H.pylori bacteria
• In Children ,ITP often starts after they have had a virus like the flu or mumps.
• Immune disorders like Rheumatoid arthritis.

Symptoms

• Petechiae: Tiny red or purple spots on the skin caused by small amounts of bleeding under the skin.
• Purple and Bruising : Purple, brown or dark patches on the skin or bruises that appear easily
• Mucosal Bleeding : Frequently nosebleeds or bleeding from the gums
• Excessive Bleeding: Very heavy periods or blood appearing in urine or stool

Symptoms according to ayurveda

Poorva Roopa (Premonitory Symptoms)
Early warning sign

• Gala Shuka Purnata : Sensation of the throat being filled with dust or biological fibers.
• Ura Vidaha : Burning sensation in the chest area.
• Amla Udgara: Sour belching or severe acid reflux.
• Sheeta Kamitva : Intense craving for cold foods and environment.
• Loha gandhi nishwasa : Breath that smells distinctively metallic or iron like.
• Aruchi & Klama: Sudden loss of appetite accompanied by unexplained fatigue

Roopa (Active Clinical Manifestations)

Active blood vitiation

• Triyakgata Raktasrava: Bleeding under the skin, which appears as tiny red or purple spots(Petechiae) or unusual bruises (purpura).
• Nasagata Raktastrava: Frequent bleeding from the nose (nosebleeds).
• Asrigdhara/Menorrhagia: Very heavy or longer then usual menstrual bleeding in women
• Mukha Raktasrava: Bleeding from the gums or the formation of bl;ood filled blisters inside the mouth.
• Raktamutra &Purisha: Presence of blood in urine or stool.
• Sarvanga Dahatva: A strong burning feeling or heat sensation throughout the body.
• Jwara: Mild to moderate fever affecting the whole body.

Jwara: Mild to moderate fever affecting the whole body.

When Pitta & Rakta imbalance remains unmanaged, it leads to severe complication

• Brahma & Daurbalya: Feeling very dizzy, lightheaded and extremely weak because of losing a lot of blood
• Abhyantara Raktasrava: Dangerous internal bleeding where blood leaks inside the body and may affect important organs like the lung, stomach, intestine or brain

Diagnosis

• • Physical examination – Check for red dots, purple spots,
  • Medical history – Review viral illness, past health issues .

Lab test –

• • Complete blood count(CBC) : Shows a low platelet count(typically below 100 × 10⁹/L), while red & white blood cell counts remain completely normal.
  • Peripheral blood smear: Examine blood cells to confirm the low number and check the size and shape of platelets.
  • Exclusion test: Screening blood tests for conditions that mimic ITP, such as HIV, hepatitis viruses or systemic lupus erythematosus

Modern treatment

• Corticosteroids: Prednisone or dexamethasone help in raising platelet counts by showing how fast the immune system destroys them .
• Intravenous Immunoglobulin (IVIG): Given by iv infusion to increase platelets count
• Anti-D Immunoglobulin: Used for specific Rh-positive patients to block platelet destruction as an alternative to IVIG.
• TOP Receptor Agonists: Medications like romiplostim and eltrombopag signal the bone marrow to produce more platelets.
• Monoclonal Antibodies: Drugs like rituximab target specific immune cells to stop them from attacking platelets.
• Avoid Blood thinners

AYURVEDIC OVERVIEW

According to the Ayurveda, Immune Thrombocytopenic Purpura(ITP) is best understood as Triyakgata Raktapitta, a bleeding caused by the imbalance of Pitta and Vata doshas and the contamination of Rakta dhatu (blood tissue) According to Acharya Vagbhata, excessive intake of foods possessing Ushna (hot), Tikshna (sharp/pungent), Katu (pungent), and Lavana (salty) rasa leads to the aggravation of Pitta Dosha. The aggravated Pitta, along with the involvement of Vata and Kapha, causes vitiation of the Rakta Dhatu (blood tissue), resulting in the development of Raktapitta. In this condition, the vitiated Pitta combines with the vitiated Rakta, leading to bleeding from various body orifices. When the vitiated blood also oozes through the Romakupa (hair follicles), the condition is known as Triyakgata Raktapitta. Triyakgata Raktapitta is primarily considered a Pitta-dominant disorder. However, as the disease progresses, Vata and Kapha also become significantly involved, transforming it into a Pitta-predominant Tridoshaja (Sannipataja) disorder. According to Ayurvedic principles, chronic or advanced diseases often progress to a Sannipataja stage, where all three Doshas are simultaneously vitiated. Due to its severe nature, complex pathogenesis, and poor prognosis in advanced stages, Triyakgata Raktapitta is classified as a Mahagada (major/severe disease).

Herbal remedies for Ulcerative Colitis by Planet Ayurveda

Planet Ayurveda is an Indian herbal manufacturing and healthcare enterprise founded by Dr. Vikram Chauhan in Mohali, Punjab. The company specializes in producing 100% natural Ayurvedic herbal supplements made from carefully selected medicinal plants. Its product range includes standardized plant extract capsules, powders, herbal teas, and liquid formulations featuring herbs such as Ashwagandha, Curcumin, and Triphala. All products are manufactured without the use of chemicals, preservatives, artificial colors, or additives, ensuring purity and authenticity. In addition to manufacturing herbal products, the company offers Ayurvedic clinical consultations and exports its products to customers worldwide, promoting traditional Ayurvedic healthcare through natural, high-quality herbal formulations.

1. 1. Immune Booster
   2. Ashwagandha Capsules
   3. Giloy Capsules
   4. Gandhak Rasayan
   5. Green Essentials
   6. Kumar Kalyan Ras
   7. Brahmi Chyawanprash
   8. Swaran Vasant Malti Ras

   Immune Thrombocytopenia (ITP)-Care Pack

   

   

   Product description:-

   1. 1. Immune Booster Capsules–

   Immune Booster Capsules are a capsule formulation designed to support healthy immune function and improve the body’s natural defense mechanisms. The key ingredients include Amalaki (Emblica officinalis), Bhumi Amla (Phyllanthus niruri), Grape Seed (Vitis vinifera), Cow Colostrum etc. These ingredients are rich in antioxidants, polyphenols, vitamins, and bioactive compounds that help combat oxidative stress and promote balanced immune responses. In disease management, the formulation supports immune modulation, enhances resistance against recurrent infections, promotes tissue repair, and improves overall vitality.

   Dosage: 1–2 capsules twice daily after meals with plain water or as directed by an Ayurvedic physician.

   1. 1. Ashwagandha Capsules–

   Ashwagandha Capsules are a vegetarian capsule formulation containing a standardized extract of Ashwagandha (Withania somnifera). Ashwagandha is a renowned Ayurvedic adaptogen that helps the body cope with physical and mental stress while supporting strength and endurance. It possesses immunomodulatory, antioxidant, anti-inflammatory, and rejuvenating properties. In disease management, it helps improve immunity, supports healthy nervous system function, promotes muscle strength, enhances recovery, and reduces fatigue associated with chronic illnesses. It also supports healthy inflammatory responses and overall well-being.

   Dosage: 1–2 capsules twice daily after meals with plain water or as directed by an Ayurvedic physician.

   1. 1. Giloy Capsules–

   Giloy Capsules are a capsule formulation prepared from a standardized extract of Giloy (Tinospora cordifolia). Giloy is widely recognized in Ayurveda as a potent Rasayana herb that supports immunity and detoxification. It exhibits antioxidant, immunomodulatory, anti-inflammatory, hepatoprotective, and antimicrobial properties. In disease management, Giloy helps regulate immune responses, reduces inflammation, supports liver health, and enhances the body’s resistance to infections. It also helps improve recovery and maintain healthy metabolic functions while reducing oxidative stress.

   Dosage: 1–2 capsules twice daily after meals with plain water or as directed by an Ayurvedic physician.

   1. 1. Gandhak Rasayan–

   Gandhak Rasayan is a classical Ayurvedic tablet formulation prepared using purified Sulphur (Shuddha Gandhak). It is considered a potent Rasayana that supports immune health and tissue rejuvenation. In disease management, it helps enhance immunity, supports healthy skin and mucosal tissues, promotes detoxification, reduces microbial burden, and improves recovery by minimizing oxidative stress and inflammation.

   Dosage: 1 tablet twice daily after meals with plain water or as directed by an Ayurvedic physician.

   1. 1. Green Essentials–

   Green Essentials is a powder formulation prepared from a blend of nutrient-rich superfoods including Spirulina, Wheat Grass, Grape Seed (Vitis vinifera) etc. It provides essential vitamins, minerals, chlorophyll, antioxidants, amino acids, and phytonutrients. In disease management, it helps improve nutritional status, supports immunity, promotes detoxification, combats oxidative stress, and enhances cellular health. Its antioxidant-rich composition supports tissue repair, energy production, and overall vitality during chronic illnesses and recovery.

   Dosage: Mix 1 teaspoon (approximately 5 g) in water or juice once or twice daily, or as directed by an Ayurvedic physician.

   1. 1. Kumar Kalyan Ras–

   Kumar Kalyan Ras is a classical Ayurvedic tablet formulation prepared using purified mineral preparations such as Swarna Bhasma, Mukta Bhasma, Pravala Bhasma, Rasa Sindoor, and Abhrak Bhasma, processed according to classical Ayurvedic pharmaceutics. Traditionally regarded as a rejuvenative formulation, it supports immunity, strength, and healthy growth. In disease management, it enhances immune resilience, supports respiratory health, promotes tissue nourishment, and improves recovery in debilitated individuals. It also acts as a Rasayana by improving vitality and strengthening the body’s natural defense mechanisms.

   Dosage: 1 tablet once or twice daily with honey, ghee, or as directed by an experienced Ayurvedic physician.

   1. 1. Brahmi Chyawanprash–

   Brahmi Chyawanprash is a herbal avaleha (herbal jam) prepared using Amalaki (Emblica officinalis), Brahmi (Bacopa monnieri), Ashwagandha, Pippali, Ghee, Honey, and numerous classical Ayurvedic herbs. It is a nourishing Rasayana that supports both cognitive and immune health. Rich in antioxidants and rejuvenating herbs, it helps improve mental performance, supports memory, enhances immunity, promotes respiratory health, and increases overall vitality. In disease management, it assists in improving resistance to recurrent illnesses while supporting healthy nervous system function.

   Dosage: 1–2 teaspoons twice daily with warm milk or lukewarm water after meals, or as directed by an Ayurvedic physician.

   1. 1. Swaran Vasant Malti Ras–

   Swarn Vasant Malti Ras is a classical Ayurvedic tablet formulation containing Swarna Bhasma, Mukta Bhasma, Maricha (Piper nigrum), Hingula, and other purified mineral ingredients, processed according to classical Ayurvedic texts. It is traditionally considered a potent Rasayana with immunomodulatory and rejuvenating properties. In disease management, it supports healthy immune responses, promotes strength, enhances tissue nourishment, improves recovery from chronic illnesses, and helps maintain respiratory health and vitality.

   Dosage: 1 tablet once or twice daily with honey, ghee, or as prescribed by an Ayurvedic physician.

   Home Remedies by Planet Ayurveda

   1. 1. • Red Juice: Red juice is quite a drink. It can be prepared with things which are obviously of red color like pomegranate,apple,beetroot,half or one carrot and one thing which is green but is important in this juice. It is amla or gooseberries.You can take the juice of one apple,one pomegranate,one beetroot,two gooseberries and two or three black grapes.Mix these well and have this juice at least once in a day.
         • Juice of Papaya Leaves:If nothing can be done like you don’t have ingredients for red juice or green juice or you want to try something extra to maintain your platelets then nothing is better than the juice of papaya leaves. Take two fresh papaya leaves and extract fresh juice. Have freshly extracted papaya juice at least twice daily. This will give you wonderful results.
         • Giloy Decoction or Juice: Giloy or Guduchi is a very famous herb of Ayurveda and of India as well. It not just has an immune modulatory effect but it can mould its effect according to the needs of the body. Giloy decoction of juice can be prepared with a giloy stem. Take a giloy stem and crush it. Boil it in water to make decoction. In case of fresh juice extract the juice from the giloy stem. It can be taken once daily in the quantity of around 50-100ml varying according to age.

   Diet In Idiopathic Thrombocytopenic Purpura (ITP)

   AVOIDE

   1. 1. • Non-veg
         • All Citric food & fruits
         • Cauliflower
         • Cabbage
         • Kidney beans
         • Green and Red chillies

   TO TAKE

   1. 1. • Egg white
         • Coconut water
         • Pumpkin seeds
         • Pomegranate
         • Pumpkin
         • Broccoli
         • Turnip
         • Green gram
         • Fennel
         • Turmeric

   Conclusion

   Idiopathic Thrombocytopenic Purpura (ITP) is an autoimmune hematological disorder characterized by isolated thrombocytopenia due to immune-mediated platelet destruction and impaired platelet production, resulting in an increased risk of bleeding. Early diagnosis through clinical evaluation and laboratory investigations, along with appropriate medical management, is essential to prevent complications. From an Ayurvedic perspective, ITP can be correlated with Triyakgata Raktapitta, involving Pitta dosha aggravation and Rakta dhatu dushti. Ayurvedic management focuses on maintaining Dosha balance, improving Rakta dhatu health, enhancing immunity (Ojas), and supporting overall well-being through proper diet, lifestyle modification, and individualized therapy. Integrative care with regular platelet monitoring and guidance from qualified healthcare professionals is important for safe and effective management of the condition.