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ABSTRACT

Isaacs’ syndrome is known as neuromyotonia, a rare neurological disorder which causes uncontrollable muscle activity. A neurological disorder is a disorder that affects the nervous system, structurally, biochemically and electrical abnormalities of the brain and spinal cord which results in the arrival of symptoms. The nerves and spinal cord are enclosed in the tough membrane which is further enclosed in the skull and is isolated by the blood-brain barrier. It can be due to genetic causes, lifestyle changes and sometimes environmental health problems. Neuroregeneration occurs in the peripheral nervous system. The nervous system is made of nerves which are like cables that carry electrical impulses between the brain and the rest of the body. Nerve cells are known as neurons which are present all over the body together with the brain and spinal cord they are known as the nervous system. There are generally two nerves that are Cranial nerves (12 pairs of nerves which originate in the brain and extend to the face and head), Spinal nerves (31 pairs of spinal nerves which branch out from the spinal cord). These nerves send you the electrical signal from one part to another which controls blood pressure, digestion and voluntary movements. In this article, we are going to discuss its causes, symptoms and ayurvedic management in detail further in the article.

INTRODUCTION

Isaacs’ syndrome is a rare neuromuscular syndrome which causes the nerves within your peripheral nervous system and causes uncontrollable muscle activity. Muscle movement occurs continuously even if the patient is in anesthesia. It is an autoimmune disease in which the body’s immune system attacks its own tissues. It is known as neuromyotonia which is autoimmune peripheral nerve hyperexcitability which is thought to be voltage-gated potassium channelopathy. Neuromyotonia can be hereditary or acquired. It is known as Continuous Muscle Fibre Activity Syndrome, Isaacs Merten Syndrome and Quantal Squander Syndrome. This condition makes the nerves fire too much which over-stimulates your muscles and reflexes and muscles which further causes muscle stiffness and excessive cramps which may affect your daily activities and sometimes affect the autonomic nervous system which leads to changes in heart rate and sweating. It is common in adults and begins between the age of 15-60 years and is more common in males than females. This disorder can be associated with many conditions such as Cancer, Hashimoto’s disease, Myasthenia gravis and vitamin B12 Deficiency.

KEY POINTS

• The sine qua non of Isaac syndrome is myokymia which is continuous muscle twitching which is seen as a bag of worms movements in the region of limbs.
• There are specific antibody markers which show nerve conduction and EMG studies.
• To relieve various symptoms one can have plasma exchange, IVIG and phenytoin.

CAUSES

1. Neuromyotonia is described in two types-
2. Acquired neuromyotonia- It is an autoimmune condition which is seen when the immune system attacks the normal cells. In Isaac’s syndrome, 50%  of people have antibodies which target the channels which control the movements of electrolytes of potassium into and out of the nerves. These in and out movements affect the nerve firing.
3. Hereditary- This is genetic and is inherited from one generation to another  
4. Myasthenia gravis
5. Small cell lung cancer
6. Peripheral nerve disorders
7. Lupus
8. Guillain barre syndrome

SYMPTOMS

1. It is a diverse disorder, which shows muscular hypersensitivity.
2. Ataxia (troubled coordinating movements)
3. Delayed muscle relaxation
4. Fatigue
5. Insomnia
6. Muscle cramping, stiffness and weakness which gets worsen up
7. Trouble in speaking and breathing if the throat is affected.
8. Muscle pain
9. Elevated heart rate
10. Increased calf muscle size
11. Excessive sweating
12. Intermittent cramps
13. Pseudomyotonia
14. Around 20% of patients suffer from Morvan Syndrome which includes symptoms such as –
15. Irregular heartbeats
16. Constipation
17. Difficulty in sleep
18. Changes in personality
19. Hallucinations

These symptoms may fluctuate in severity and frequency which can affect the muscles in the body but commonly affects the arms and legs.

DIAGNOSIS

1. Blood tests
2. Electromyograms (nerve conduction)
3. CT Scan
4. MRI
5. Urine tests

DIFFERENTIAL DIAGNOSIS

1. Hereditary neuromyotonia or myokymia syndrome
2. Cramp fasciculation syndrome
3. Amyotrophic lateral sclerosis (ALS)
4. Spinal muscle atrophy

TREATMEN

The aim of treatment is to maximise daily functions and Isaac syndrome is associated with autoimmune disease and malignancy. The treatment includes-

1. Anticonvulsant medications to relieve stiffness, spasms and pain
2. Immunosuppressive medications
3. Intravenous immunoglobulin
4. Oral corticosteroids
5. Plasma exchange to filter out toxins and unhealthy antibodies from the blood
6. Botox injections

AYURVEDIC MANAGEMENT

The nervous system is the controlling, regulatory and communicating system in the body. The nervous system consists of the brain, spinal cord and other sensory organs which connect these organs with the rest of the body. Vata dosha is responsible for the control of all nervous systems in the body. Diseases caused by the Vata in the vitiated condition are known as vatavyadhi. Vata is a tantra which runs the body and controls the mind, senses and perception. There are more than 80 nanataja vyadhi and divides the Vata vyadhi into two types- Dhatukshyajanya and Margavrodhajanya. In the case of Dhatukshyajanya pain is reduced by touching or giving some pressure. But in the case of Margavrodhajanya, the pain is aggravated by touching or applying pressure.

Mainly Prana Vata is located in the head i.e brain,  Prana Vata circulated in the chest and controls the function of the heart and lungs and provides proper perception to sense organs. Vata needs to be balanced between stability and stabilising the balance of Vata doshas. When these doshas are vitiated it creates havoc inside our body and triggers the pain. It acts on the weakest point of our body and triggers the pain and disease itself.  There is some relation of pitta doshas with the nervous system as the brain is the seat of sadhaka pitta, The tarpaka Kapha is located in the head around the brain which helps to nourish the sense organs and acts as a buffer.

CAUSATIVE FACTORS

• Dry foods
• Excessive indulgence in sexual activity
• Improper administration of Vamana, virechana
• Excessive bleeding
• Excess thinking, fear and grief
• Fasting in excess

PATHOGENESIS

Vata dosha on aggravation gets filled in the rikta srotas and channels of the body and loses their qualities such as smoothness and protective sheaths. When these srotas get occupied Vata will produce many ekanga (limited to particular parts of the body) and Sarvanga (affects the whole body) diseases.

TREATMENT

1. Regular practice of danta dhavana, Mukha prakshalana.
2. Abhyanga- Oil has the property which opposes the Vata doshas and a good massage helps to calm the muscles for some time and shows drastic changes.
3. Pratimarsha Nasya
4. Dhoomapanam
5. Swedana- In this a person is subjected to the wooden box except for the head and the box covers the neck to the leg which is helpful.
6. Basti- Basti is helpful in treating Vata vyadhi, It is similar to enema and decoction which usually contains Vata alleviating drugs.
7. Takra Dhara- This is used against dosha vitiation and is perfect for calming down the muscles and providing good sleep.

HERBS USEFUL IN ISAACS SYNDROME

1. SHALPARN

Shalparni (Desmodium gangeticum) helps to balance all the tridoshas of the body and helps to improve strength. It is a useful herb used in the treatment of Asthma and chronic respiratory diseases and helps in relieving the burning sensation. It is useful in bronchitis as it helps to eliminate the waste which further leads to the formation of ama and removes the excess mucus which is present in the lungs. It has antioxidant properties and various constituents which are helpful in neurological problems.

2. Gokshura

Gokshura (Tribulus terrestris) is helpful in bodybuilding and acts as an aphrodisiac. It helps to improve muscle strength and cleanses the urinary system and acts as a lithotriptic activity. Gokshura has anti-inflammatory properties and helps to heal the wound. It balances the tridoshas of the body, is helpful in cardiac disorders and improves body nourishment and relieves abdominal colic pain.

3. Ashwagandha

Ashwagandha (Withania somnifera) is helpful in the treatment of depression and anxiety and has antioxidant properties and promotes cardiac health. It is helpful in cardiac diseases and helps to relieve tissue depletion. Improves the quality of sleep, brain and mental health. It is one of the best herbs for sexual disorders so improves sexual desires, maintains healthy blood pressure and reduces sugar levels.

4. GILOY

Giloy (Tinospora cordifolia) is a helpful herb used in the treatment of fever and acts as an immunomodulator. Helps to balance the tridoshas, acts as a rejuvenator, relieves the burning sensation and in many diseases related to the liver. Helpful in many heart diseases and improves the vision of the eyes and in seronegative arthritis. Helps to boost immunity and is useful in treating intestinal cystitis

5. MORINGA

Moringa (Moringa oleifera) is a useful herb which is useful in worm infestation and helpful in the digestive system and heart circulatory systems. Helps to balance the Kapha and Vata disorders. This herb has a pungent taste, useful in nasya. It is helpful in maintaining high cholesterol levels which reduces the risk of heart diseases. Useful in skin infections and prevents the body from sexually transmitted diseases.

HERBAL REMEDIES BY PLANET AYURVEDA FOR ISAAC’S SYNDROME

Planet Ayurveda is a worldwide famous ayurvedic online store. Ayurveda provides a spectacular life without any worry. All the medications formulated by our great ancestors or by our own creations are made seeing today’s current situation in society. All the medicines are quality assured, chemical free and pure vegetarian. The formulations made by planet Ayurveda cause no side effects and are beneficial to one for having healthy living and balancing all the doshas in the body.

PRODUCTS LIST

1. BOSWELLIA CURCUMIN
2. ASHWAGANDHA VATI
3. BRAHMI GHRIT
4. VRIHAT VATCHINTAMANI RAS
5. RASRAJ RAS
6. VIKRAMPRASH
7. TELOMERE EXTENSION
8. MORINGA CAPSULE

PRODUCTS DESCRIPTION

1. Boswellia Curcumin

Boswellia Curcumin is a polyherbal capsule which is made by planet ayurveda using ingredients such as Shallaki (Boswellia serrata) and Curcumin (Curcuma longa). This capsule has anti-inflammatory properties and is useful in joint inflammation and cervical vertebrae. It is helpful in neuropathy and malignancy disorders which are controlled by turmeric and shallaki. Shallaki has a property which boosts health and is useful in alleviating Vata doshas.

Dosage– 1 capsule twice daily after meals with plain water.

2. Ashwagandhaghan Vati

Ashwagandhaghan Vati is a herbal tablet formulation which is made by planet Ayurveda using Ashwagandha (Withania somnifera). These tablets balance the imbalance of Vata and Kapha doshas, Help to normalise the blood pressure and calm down the nervous system and act as a diuretic. Useful in many disorders such as CNS disorders, reproductive disorders and in many skin diseases. It promotes general wellness and helps to lower the unwanted movements of nerve impulses.

Dosage– 1-2 tablets twice daily with lukewarm water

3. Brahmi Ghrit

Brahmi Ghrit is a classical ayurvedic product which is made by planet ayurveda using ingredients such as Brahmi (Bacopa monnieri), Vacha (Acorus calamus), Shankhpushpi (Convolvulus pluricaulis) and more. This ghrit is helpful in improving intelligence and balancing the tridoshas of the body. It is helpful in stress disorders, myalgia and in female fertility. This ghrit is helpful in calming the nervous system and avoids unwanted muscle twitching.

Dosage– 1 tsp daily after meals with warm water

4. Vrihat Vatchintamani Ras

Vrihat Vatchintamani Ras is a classical ayurvedic product which is prepared by planet ayurveda using ingredients such as Swarna Bhasma (Fine powder of gold), Loha Bhasma (Fine powder of iron) and many more. This is made of metals and minerals which are capable of alleviating disease and helpful in neurological disease and helping to reinstall normal nerve function and decreasing involuntary movements.

Dosage-1 tab twice daily with plain water after meals.    

5. Rasraj Ras

Rasraj Ras is a classical ayurvedic product prepared by planet ayurveda using ingredients such as Parada (Purified mercury), Loha Bhasma (Calx of iron), Lavanga (Syzygium aromaticum), Ksheera Kakoli (Fritillaria roylei) and many more. This tablet is helpful in neuromuscular conditions such as strengthening the nerves and muscles. This is helpful in alleviating the Vata doshas and restoring healthy nerve functions.

Dosage– 1-2 tablets twice daily chewed with plain water after meals.

6. Vikramprash

Vikramprash is a avaleha form which is prepared by planet ayurveda using various ingredients such as Bilva (Aegle marmelos), Syonak (Oroxylum indicum), Patla (Sterospermum suveolens) and many more. Vikramprash has an incredible health tonic for nerves and helps to enhance the brain and function of nerves. Best to alleviate the Vata doshas and restore the nerve functions normally.

Dosage– 1-2 tsp twice daily

7. Moringa Capsules

Moringa Capsule is a single herbal capsule which is made by planet ayurveda using a single extract of Moringa (Moringa oleifera). This capsule is helpful in balancing Vata and Kapha doshas which helps to strengthen the body and alleviate the Vata doshas. It helps to nourish the body and bring back the activities of nerves to normal. These capsules are helpful in improving and providing strength to teeth and provide glowing skin.

Dosage- 1-2 capsules twice daily

8. Telomere Boostup

Telomere boostup is polyherbal capsules made by planet ayurveda using Ashwagandha (Withania somnifera), Giloy (Tinospora cordifolia), Amla (Emblica officinalis) and many more. Amla is helpful in nourishing and is capable of alleviating the tridoshas, Ashwagandha strengthens the body and calms down the over-excited nerve and is properly digesting the ama and is helpful in autoimmune conditions.

Dosage- 1-2 capsules twice daily

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040

CONCLUSION

Isaacs’ syndrome is known as neuromyotonia, a rare neurological disorder which causes uncontrollable muscle activity. A neurological disorder is a disorder that affects the nervous system. Isaacs’ syndrome is a rare neuromuscular syndrome which causes the nerves within your peripheral nervous system and causes uncontrollable muscle activity. It is common in adults and begins between the age of 15-60 years and is more common in males than females.  Vata dosha is responsible for the control of all nervous systems in the body. Diseases caused by the Vata in the vitiated condition are known as vatavyadhi. Further, we discussed the herbal remedies which are made by planet Ayurveda which are helpful in this disease without causing any side effects.