Category: Acidity/ Heartburn

Alternate to Tinidazole and metronidazole for Giardiasis

Abstract

Giardiasis is a protozoal infection. This disease affects our intestines. There are billions of bacteria in our intestines which are helpful to digest and absorb nutrients. But infectious bacteria or organisms cause infection in our gut. Giardiasis infection is caused by flagellate giardia intestinalis called giardia lamblia. This disease is spread through people to others. In this disease a person is having diarrhea, vomiting, abdominal cramps, bloating, loss of appetite, lethargy, abdominal tenderness and distension. The treatment of choice in Allopathy is tinidazole and metronidazole. So in this article we are going to discuss tinidazole and metronidazole along with effective Ayurvedic medicines in detail.

Giardiasis

What is Tinidazole and Metronidazole?

These drugs come under the class of antiamoebic and antiprotozoal drugs. These drugs are useful in infection which is caused by a protozoa Entamoeba histolytica. These two drugs are the prototype of nitroimidazole which was introduced in 1959 for trichomoniasis. But later on it is found that it is a highly active amoebicide. Metronidazole and Tinidazole have broad-spectrum cidal activity against anaerobic protozoa. But they do not affect aerobic bacteria. They are selectively toxic to anaerobic and microaerophilic microorganisms. After entering into the bacterial cell by diffusion, the nitro radical of these drugs reduced the activity of the bacteria. This nitro radical exerts cytotoxicity (probably by damaging DNA). In addition metronidazole and tinidazole have been found to inhibit the cell mediated immunity which induce mutagenesis and thus further cause radio sensitization. These both drugs are used in intestinal as well as extra intestinal infections also.

Pharmacokinetics

Metronidazole and Tinidazole are almost completely absorbed from small intestines. Little unabsorbed drugs reach the colon. Metabolism occurs in the liver by oxidation and glucuronide conjugation. Plasma t1/2 of metronidazole is 8 hours.

Adverse effects

Adverse effects of these two drugs are relatively frequent and unpleasant. The side effects of these two drugs are

  • Anorexia, Nausea, Metallic taste, abdominal cramps, loose stool are the most common side effects.
  • Headache, glossitis, dryness of mouth, and dizziness are the less frequent side effects.
  • Prolonged use of these drugs causes peripheral neuropathy and CNS effect.

Contraindications

It is contraindicated in the following

  • Neurological disease
  • Blood dyscrasias
  • First trimester of pregnancy

Uses of Metronidazole and Tinidazole

These are useful in

  • Amoebiasis
  • Giardiasis
  • Trichomonas vaginitis
  • Anaerobic bacterial infections
  • Helicobacter pylori gastritis

Dosage

  • Metronidazole- 400 mg TDS
  • Tinidazole- 0.6 gm

Difference between Metronidazole and Tinidazole

Tinidazole is mainly equally effective congener of metronidazole, but some little difference is there

  • Its plasma t1/2 is 12 hour
  • Duration of action is longer than metronidazole
  • It is more suited in single dose

Because of the adverse effects of these medicines, we are introducing some safe and herbal products for the treatment of giardiasis

Herbal Products for Giardiasis

Planet Ayurveda offers the best herbal products for the treatment of giardiasis. This is a manufacturing company which manufactures various herbal products and these herbal products are made using the standardized extracts of potential herbs. Also these are made under expert advice.

Herbal-products-for-giardiasis

Herbs for Giardiasis

This company offers following herbal products for giardiasis

  1. Sanjivani Vati
  2. Mahashankh Vati
  3. Wormistop Capsules

Product description

1. Sanjivani Vati

This is a classical Ayurvedic formulation. It is a natural source of life and health. this vati contains very potent herbs like- sonth (Zingiber officinale), harar (Terminalia chebula), bahera (Terminalia bellerica), amla (Emblica officinalis), vidanga (Embelia ribes), giloy (Tinospora cordifolia), shuddha Bhallataka (Purified Semecarpus anacardium) etc. It has antipyretic and diaphoretic properties. It is also known as the best Aama (endotoxins) digestive. It also helps in maintaining the metabolism.

Dosage: 1 tablet twice a day after meals with plain water

2. Mahashankh Vati

This is also a classical ayurvedic medicine. This is a natural solution for abdominal pain, acidity and indigestion. This Ayurvedic formulation contains chitrak (Plumbago zeylanica), danti (Baliospermum montanum), sajjikshara (natural sodium carbonate) etc. this herbal product of planet ayurveda is best for digestive disorders such as indigestion, abdominal pain, disturbed bowel movement, loss of appetite etc. It has anti-inflammatory and anti-helminthic properties.

Dosage: 1 tablet twice a day after meals with plain water

3. Wormistop Capsules

These are poly herbal formulations of Planet Ayurveda. This formulation is helpful in managing infectious diseases like giardiasis. These capsules are made using the standardized extracts of palaash (Butea monosperma), tulsi (Ocimum sanctum), vidanga (Embelia ribes), sonth (Zingiber officinale). These ingredients are very effective for treating digestive problems. It is helpful in alleviating the digestive symptoms like indigestion, bloating, pain, excessive hunger etc.

Dosage: 1 capsule twice a day after meals with plain water

Conclusion

As we saw that allopathic medicines have drastic side effects. They are helpful in treating giardiasis but left with side effects in the body. So it’s better to take Ayurvedic medicines for better results. Moreover, these ayurvedic medicines are left with no side effects and treat the disease from its root cause. So one should use herbal products of Planet Ayurveda and enjoy a happy and healthy life.

Treatment of Strongyloides stercoralis hyperinfection syndrome

Abstract

Strongyloides stercoralis is a very small nematode which parasites the mucosa of the upper part of the small intestine, often in large numbers.the eggs hatch in the bowel but only larvae are passed in the feces. In moist soil they moult and become the infective filariform larvae. After penetrating human skin they undergo a development cycle similar to that of hookworms but the female worms burrow into the mucosa and submucosa. Some larvae in the intestine may develop into filariform larvae which may then penetrate the mucosa or perianal skin and lead to auto infection and a very persistent infection. In this article we will mainly discuss the hyperinfection due to  Strongyloides stercoralis and what symptoms it creates along with its Ayurvedic management.

Introduction

Strongyloides is the parasite that has more prevalence in the tropical and subtropical regions of the world. Hyperinfection syndrome due to these parasites is ensured in patients that are having imapired cell mediated immunity. Imapaired cell mediated immunity is common in patients who are being administered with steroidal treatment and with drugs which are responsible for immune system suppression. Hyperinfection syndrome only happens when there is acceleration of the normal life cycle of S. stercoralis increasing the worm burden within the reproductive route.Then wide spread of the larvae of this parasite takes place out of the gut area involving organs like heart, liver, brain and urinary tract.

Strongyloides stercoralis hyperinfection syndrome

Clinical manifestation of Strongyloides stercoralis hyperinfection syndrome

The symptoms are similar to classic strongyloidiasis which includes nausea, vomiting, diarrhea, abdominal pain, weight loss, GI hemorrhage, cough, fever and difficulty in breathing. But in case of hyperinfection with accelerated life cycle of parasite catastrophic clinical manifestations like shock, intravascular coagulation, meningitis, respiratory and renal failure.

Moreover, major anatomical changes take place in the duodenum and jejunum. The parasites can be identified in the crypts of lieberkuhn and in mucosa and deposited eggs are sometimes present in the depths of these burrows. The inflammatory action is quite variable and only in the more severe instances is there a mixed leukocytic infiltration, characteristically containing many eosinophils. Much of this infiltration may be attributable to secondary infection.

Diagnosis

The diagnosis of this condition is usually done after examining the stool. Sterile slides are made for filariform larvae. Due to accelerated activity usually parasites are being diagnosed in the stool test. Moreover, a complete blood count is done to take a complete idea of infection and its severity. Urine tests can also be advised.

Treatment

The first line of treatment for strongyloides include ivermectin which eradicated around 80% of parasites. Other agents include thiabendazole and albendazole. In case of shock patients need in door admission along with fluid replacement therapy. Administration of antibiotics through intravenous routes can also be done. If patients have low hemoglobin levels immediate administration of blood units is required.

Herbal Remedies by Planet Ayurveda

Planet Ayurveda is a leading herbal manufacturing unit which manufactures herbal products that are very effective in managing multiple conditions. These products are manufactured using potent herbs and are prepared under the guidance of expert Ayurvedic doctors. The manufacturing team works under their guidance to avoid any kind of compromise with product quality. Our products do not contain any kind of fillers, additives, adulterants and are totally safe to use without any side effects. The herbal products are manufactured using potent and efficient herbs.

Herbal Remedies for Strongyloides stercoralis hyperinfection syndrome

Buy Now

Following are the products offered by Planet Ayurveda for the management of Strongyloides stercoralis hyperinfection syndrome

  1.  Wormistop capsules
  2.  Sanjivani Vati
  3.  Mahashankh Vati
  4.  Digesto plan syrup
  5.  Giloy Capsules
  6.  Curcumin capsules

Products Description

1. Wormistop capsules

Wormistop has constituents like palash (Butea monosperma), tulsi (Ocimum sanctum),  sonth (Zingiber officinale) and vidang (Piper retrofractum). As the product name suggests it is very effective in removing parasites from the intestine and eradicates around 80-90% of worms from the human intestine. It also improves digestion and soothes the mucosa of the intestine.

Dose: Two capsules twice  a day after meals.

2. Sanjivani Vati

Sanjivani vati is known as a medication that infuses life. This is a classical ayurvedic formulation consisting of sonth (Zingiber officinale), haritaki (Termenalia chebula), giloy (Tinospora cordifolia) and many others. It helps in getting rid of accumulated endotoxins and also helps in removing worms from intestines. It creates such an environment in the bowel which is not fit for the survival parasite hence leading to parasite free bowel.

Dose: Two tablets twice a day after meals.

3. Mahashankh Vati

This is a classical formulation having constituents like pancha lavana (five types of salts), shankh bhasma (ashes of pearl), pippali (Piper longum)  and many others. These Help in reducing symptoms related to the digestive system like pain in abdomen, indigestion, worms in intestine, acidity and gastritis. Shankh bhasma in this is very effective in treating chronic constipation and also helps in removal of parasites from intestine by creating a non favourable environment.

Dose: Two tablets twice a day after meals.

4. Digesto plan syrup

Digesto plan syrup is an ultimate composition of herbs like amalaki (Emblica officinalis), haritaki (Terminalia chebula), bibhitaki (Terminalia bellerica) and others. This syrup is potent in reducing anorexia, indigestion and abdominal pain. It improves digestion and has abundant healing features. It helps in balancing toxins in the digestive system which creates a favorable environment for parasite growth.

Dose: Two tsp twice a day after meals.

5. Giloy Capsules

Giloy (Tinospora cordifolia) is an amazing herb that helps in improving the immunity of the body. It also behaves as an immunomodulator in immune-compromised cases. Giloy is an amazing herb that works according to the way your body needs it due to its vichitra pratya rabdha property. Giloy is very much safe to use in any age group.

Dose: Two capsules twice a day after meals.

6. Curcumin capsules

Curcumin capsules are made from the curmin extract of haridra (Curcuma longa). Haridra has amazing properties like it behaves as an antibacterial, anthelmintic, and also bears analgesic features. This formulation is very effective in dragging out worms from the intestine and also helps in enhancing the immunity of the body.

Dose: Two capsules a day after meals.

Contact Planet Ayurveda to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214030 Or Check Website – www.PlanetAyurveda.com

Conclusion

Strongyloides stercoralis hyperinfection syndrome is a condition which ultimately is the result of strongyloides infection ignorance. Patients must stay alert and should notice general symptoms related to worm infestation because long term ignorance can be deadly.