Diabetes & Complications Archives | Page 5 of 30

Herbal Treatment of Glycogen Storage Disorder

What is glycogen?

Glycogen is the primary carbohydrate stored in the liver and muscle cells of animals. Glucose is stored inside the cells in the form of glycogen. The sugar needed for the body to provide energy for daily metabolic activities are provided by the glucose. And this glucose is converted into glycogen and also glycogen is catabolized back into glucose as per the times of requirement. There are a number of enzymes that accompany the process too.

So the process of converting glycogen back to glucose at times of immediate energy requirement to maintain the blood glucose levels is called glycogenolysis and the process of forming glycogen from glucose is called glycogenesis. Takes place when the blood glucose levels are sufficient or to allow the storage of excess glucose in liver and muscle cells.

What are glycogen storage disorders?

Glycogen storage disorders are formed due to the malfunctioning of a protein or enzymes (enzymes are made of proteins) responsible for glycogenolysis or gluconeogenesis. The enzyme disorders are the main reason why there will be an inadequate amount of glycogen produced in the body or the resultant effect like abnormal glycogen production.

If the enzymes linked with the glycogenolysis are affected it will lead to a low or excess levels of glucose in blood too. Resulting in conditions like hypoglycaemia (low levels of glucose in the body).

Different types of glycogen storage disorders.

Depending on which enzyme is lacking or functioning abnormally, there are mostly 12 types of glycogen storage disorders. The disorders likely affect the cells of the liver and muscles. It also tends to affect the kidney, heart, blood vessels, bowels, and the neural system also gradually. The important ten types being as follows,

Von Gierke’s disease (type I : most common)
Pompe’s disease (type II)
Forbes-cori disease (type III)
Andersen’s disease (type IV)
Mc ardle’s disease (type V)
Hers disease (type VI)
Tarui’s disease (type VII)
Liver phosphorylase kinase deficiency (type IX)
Fanconic- Bickel syndrome (type XI)
Lewis disease (type 0)

Glycogen Storage Disorder

How do you get glycogen disorders and what are the symptoms?

Mostly the glycogen disorders are inherited. Passed on through families via genes. The symptoms depend on the type of disorder.

Type I, IV, VI, IX affects the liver.
Type V, VII affects muscles.
Type III affects both muscles and liver.

The common systems will include

In children

Slow growth along with weak muscles.
Low blood sugar levels leading to sweating, tremor, confusion, uncontrolled muscle movements and convulsions, drowsiness etc.
Enlarged liver which doctors inspect on child’s tummy.
Obesity and kidney problems
Bleeding disorders and clotting issues.

In case of teenagers and adults it can lead to fatigue and exhaustion even at the slightest of physical activities. Muscles can be weak and might even ace. Few disorders depending upon their underlying reasons can affect your immune system making you susceptible to infections.

Diagnosis and Treatment

Blood tests, biopsy and scanning are most adopted medical techniques to diagnose glycogen storage disorders. For treatment we need to stabilize that disarray in the glycogen and glucose levels of blood. Diet plan will help a lot. In Ayurveda a healthy diet and necessary physical activities corresponding to the health issues will heal your body to a greater extent. So stick to a diet plan. High protein content if given as an input and the use of nutritional supplements like glucose can be helpful.

Now the tricky cases appear as well, when the patients stop responding to nutritional supplements. In those instances we may occasionally go for liver transplant. For immunity to decrease, a regular antibiotic protection for the body to cope up against infection may also be adopted. Replacement therapy for enzymes are also administered now to reverse the condition ensuring their optimal functioning in metabolic reaction

So if you are searching for nutritional supplements, here are some of our best choices from Planet Ayurveda. Planet ayurveda is a trusted and famed organisation offering products across all over the world. The experts of planet ayurveda suggests some of the formulations for the management of these disorders which are as follows :-

Kumar kalyan ras
Energo Plan syrup
Arogyavardhini vati
Nourish Maxx
Ashwagandha Capsules
Chanderprabha vati

Products Description

1. Kumar kalyan ras

It is a herbal mineral known to treat paediatric and heat related ailments with the help of their herbal formulations. The ingredients being kumari rasa (Aloe Vera juice extract), sheedha shuddha parada (purified mercury), abhraka basma (purified and processed mica) and a lot more ingredients blessed with therapeutic value. The herbal formulation is known for their ability to bring about the vitiated or decreased levels of pitta dosha back to their normalcy. It is to be consumed as 1 daily in chewable form.

Dosage- 1 tablet once a day with plain water after meals

2. Energo Plan syrup

With the magical combination of herbs including amalaki (Emblica officinalis), ashwagandha (withania somnifera), gokshura (tribulus terrestris) and pippali (piper longum) this syrup restores your energy level and maintain the active endurance power within the body. Planet ayurveda’s energoplan syrup could be consumed daily by all family members. Its formulations will protect the body from harmful toxins and pillars the natural immune responses of the body.

Dosage- 2 tsp twice daily after meal

3. Arogyavardhini vati

This is an ayurvedic medicine in capsular form produced by planet Ayurveda to help fight against fever, skin and liver diseases. The formulations ate tridosha pacifiers making the body’s optimal balance on vata, pita and kapha doshas within an endurable limit. It acts as an active digestive stimulant and improves bio-fire thereby keeping endotoxins in the body. The ingredients like haritaki (chebulic myrobalan fruit),amalaki (indian gooseberry), tranda and neem juice extracts help the same purpose.

Dosage– 2 tablets twice a day with plain water after meals

4. Chanderprabha vati

The 120 capsules tablets are more than enough for your nutritional requirements on a daily basis. It improves the overall functioning of the body. It brings back the disrupted kapha dosha levels back to normalcy as well as assists in the maintenance of optimal levels of vata. The ingredients like curuma longa (haridra), amala, guduchi(tinospora cordifolia) and pippali (piper nigrum) are known to weaken insulin resistance by 88% and enhance glucose uptake by the cells. Their weak anti-infective properties also come handy in conditions like glycogen storage disorders.

Dosage– 2 tablets twice a day with plain water after meals

5. Nourish Maxx

This is the pure vegan formula for nourishing the whole body. This can be your best choice of natural supplement to be coupled with a low fat diet and an active lifestyle. Prepared out of the herbal combinations containing shatavari (Asparagus racemosus), safed musli (Chlorophytum borivilianum), ashwagandha (Withania somnifera) and gokshura (Tribulus terrestris). It is the plant based protein powder for better muscle strength to be consumed either in powder form or by boiling in water. This helps to improve tissue nutrition thereby providing strong and healthy movements and an effective motor activity system in the body.

Dosage- 1 tsp twice daily with plain water after meals

6. Ashwagandha Capsules

This is a renowned rejuvenative herb in Ayurveda widely used as an adaptogen for coping up with physiological as well as psychological stress. Ashwagandha pacifies Vata and Kapha because of its hot potency and unctuous nature. It is best known for supporting optimal anabolic reactions in the body. The same which we have incorporated in our capsules.

Dosage– 2 capsules twice daily with plain water after meals

Contact my assistant to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214030 Or Check Website – www.PlanetAyurveda.com

At last , we can conclude that the above-mentioned herbal formulations are very good and effective in managing Glycogen storage disorders.These formulations are free from any kind of preservative, chemical, additive and preservative and do not produce any adverse effects. For more queries you can consult online through herbalremedies123@yahoo.com.

What is Fasting Insulin and its significance for Diabetic patients?

Abstract

Diabetes mellitus is a non communicable disease but is spreading like a pandemic all over the world. Each and every house is having at least two members who are diagnosed with diabetes. The commonest type of diabetes is diabetes mellitus type 2 but the patients of diabetes type 1 are also increasing day by day. Diabetes mellitus is a clinical syndrome that is characterized by hyperglycemia due to absolute or relative deficiency of insulin. In this article we will mainly discuss the significance of fasting insulin with respect to insulin dependent Diabetes Mellitus or diabetes type 1 and also non insulin dependent diabetes or diabetes type 2.

Introduction

Diabetes is worldwide in distribution and the incidence of both types of primary diabetes, i.e insulin dependent diabetes mellitus (IDDM) or diabetes mellitus type 1 and non insulin dependent diabetes (NIDDM) or also known as diabetes mellitus type 2. However prevalence of both varieties varies considerably in both parts of the world. This Seems to be due to differences in both genetic and environmental factors. To Begin with almost certainly the term diabetes mellitus embraces a heterogenous group of disorders having differing modes of inheritance. Agreement appears to be near at hand that IDDM and NIDDM exhibit substantial genetic differences.

Diabetes mellitus

Stages of Diabetes

1. Overt or manifest diabetes

It refers to the fully expressed clinical syndrome. This stage of disease is characterized by fasting hyperglycemia, glucosuria and usually three p’s that are polyuria, polydipsia and polyphagia.

2. Subclinical diabetes

Subclinical diabetes is understood when the patient is completely asymptomatic and fasting blood glucose level is usually normal but the post prandial level (glucose levels after two hours of meal) is frequently elevated.

3. Latent or stress diabetes

These patients are at the risk of developing overt diabetes. It basically refers to a person who is completely asymptomatic and under ordinary condition is normoglycemic and has a normal glucose tolerance. But under stress like pregnancy, infection and other serious conditions temporary carbohydrate intolerance develops.

4. Prediabetes or potential diabetes

This is a conceptual state which can be applied only retrospectively to the period of time preceding carbohydrate intolerance.

Pancreatic pathology for insulin dependent diabetes mellitus

Three outstanding features characterise the pathological picture of prediabetic pancreas in IDDM

‘Insulitis’ which is the infiltration of the islets with mononuclear cells.
The initial patchiness of this lesion with, until a very late stage, lobules containing heavily infiltrated islets commonly seen immediately adjacent to unaffected lobules.
The striking beta cell specificity of the destructive process within infiltrated islets where the glucagon and other hormone secreting cells invariably remain intact.

Things about insulin

Insulin is a peptide hormone secreted by beta cells in pancreatic islets of langerhans and its main function is to lower the serum glucose levels and hence promote anabolism. It is a normal growth factor required for development. Glucose production and secretion by the liver is strongly inhibited by high concentration of insulin in the blood. Decrease or absence of insulin activity results in diabetes mellitus of either type 1 or type 2. Human insulin protein is composed of 51 amino acids and has a heterodimer of an A- chain and a B-chain which are linked together by disulfide bonds.

Fasting insulin

What is fasting insulin?

Fasting insulin is the name given to a diagnostic test which is used to measure the amount of insulin in blood. As mentioned before insulin is very much important for utilization of blood glucose and hence maintaining rights levels of it. In absence of insulin a condition called hyperglycemia usually occurs. So determining correct levels of insulin in blood is necessary so as to evaluate what exactly is the condition.

Insulin test preparation

Fasting insulin requires at least 8 hours of fasting. This means that before giving a blood sample, a patient should have not eaten anything for around 8 or more than 8 hours.

Purpose of fasting insulin

To find reasons for hypoglycemia
Diagnosing insulin resistance
To find out tumors on the pancreases.
This tumor is called insulinoma.

Test results showing insulin resistance or no insulin resistance

If your body cells have developed insulin resistance then fasting insulin is more than 48pmol/L.
If your body cells are not having any kind of insulin resistance then fasting insulin is 18-48 pmol/L.

Importance of fasting insulin with respect to hyperglycemia or both form of diabetes

Insulin as mentioned earlier is very important as it is responsible for glucose take up by the cells. Our body cells like cells of muscle tissue, cells of various organs use glucose as a source of energy. They are having specific insulin receptors. Insulin is attached to these receptors and hence the glucose is binded to it. Then this glucose is taken up by the cells which then convert it into energy or store it for later use as a source of energy. But if these receptors do not determine insulin than glucose uptake by the cells does not take place or in other scenarios due to pancreatic cell destruction as a result of the autoimmune process there is absolute deficiency of insulin resulting in hyperglycemia.

So, advising fasting insulin is of great importance in both above mentioned cases. Reason is, this test help in determining:

The exact levels of insulin in body
Determining the type of diabetes especially in case of children
Deciding the type of diet which can be followed
Determining the units of insulin which are to be administered.

Conclusion

Diabetes is no doubt setting its roots deep and deeper into our society. Though we have many effective ways to deal with this group of conditions but still it becomes challenging with each and every patient diagnosed. It is very important to understand that this condition is related to both genetic and environmental factors along with some personal habits. Moreover insulin, whose deficiency is the main reason for hyperglycemia cannot be generated through medicines but its requirement is fulfilled by administration of synthetic insulin.