Category: Arthritis / Bone / Joint Health

November 23, 2023

Osteogenesis Imperfecta/Brittle Bone Disease Treatment in Ayurveda

ABSTRACT

Osteogenesis imperfecta (OI) also called the brittle bone disease is a genetic bone disorder inherited from parents to the new born babies and are born with this disorder and due to this the bone breaks easily better to say that their bones are fragile which fractures even with a very mild trauma, possibly by crawling or walking too. As the name “Osteogenesis imperfecta” itself says – imperfect formation of the bone. This condition is considered to be an irreversible life long condition. It is a rare condition found in babies but once born with this condition they have to deal with it forever. This disease is also classified to further four types according to the degrees of severity. The management of this particular condition just needs to prevent fracture and deformity of the bone. Ayurveda also considers this condition to be Sahaja Vyadhi (genetic disorder) and provides a number of combinations of herbal drugs for the management and improvement of the condition.

INTRODUCTION

Osteogenesis imperfecta (OI) or brittle bone disease is a rare disorder of the bone in which the babies are born with lower bone density that makes their bone fragile and ultimately prone to fractures. This genetic disorder is caused due to abnormally formed bones. The signs and symptoms vary according to the severity of the disease. This condition can also be determined before birth during intrauterine life by a process known as amniocentesis. However type 1 that is considered to be the mildest one among them is commonly found.

Symptoms of Osteogenesis Imperfecta

Listed below are the types of Osteogenesis imperfecta according to the grade-

  1. Type I – this is the mildest form of OI that is the commonest too.
  2. Type II – this type is considered to be the most severe one. If affected with this type of OI the child may be born with shorter arms, legs and a softer skull that does not let the newborn survive more than a week or a year.
  3. Type III – this type of OI has almost all the features of type II but their life expectancy is normal.
  4. Type IV – this type of OI can be diagnosed at birth and do not attain fractures until they start walking or crawling.

There are few other types of Osteogenesis imperfecta (OI) but are very rarely found.

CAUSES

This disorder is caused due to genetic abnormality. The affected gene can be passed by any of the two parents. The passed genes due to some spontaneous mutation attains abnormality that causes Osteogenesis imperfecta.

SIGNS AND SYMPTOMS

Symptoms or signs of OI completely depend upon the grade of the disease. However there are some symptoms in common, that includes –

  1. Fragile bone that are more prone to fractures
  2. Weakness of muscles
  3. Joint hypermobility
  4. Curved spine
  5. Malformed or undeformed long bones
  6. Loose joints
  7. Barrel shaped chest
  8. Loss of hearing
  9. Fatigue
  10. Small stature
  11. Soft and mal aligned teeth
  12. Breathing difficulties
  13. Discoloration of sclera (it looks purple, blue or grey)
  14. Discoloured teeth
  15. Triangular shaped face
  16. Deformities of the chest wall (Barrel shaped or pigeon chest)

INVESTIGATION

  1. Physical examination can be done
  2. X Ray – to check for fractured or deformed bones.
  3. DEXA scan
  4. Bone biopsy
  5. Genetic testing

TREATMENT OF OSTEOGENESIS IMPERFECTA

There is not any treatment for the reversement of Osteogenesis imperfecta, however certain measures can be taken for the prevention of further complications. This includes –

  1. Preventive orthopaedic treatment that may consist of  bracing or splinting of several weight-bearing joints like knees, ankles or legs.
  2. Medicinal treatment for better strength of bones.
  3. Dental therapy can also be done as the  teeth are brittle.
  4. Physical therapy can also be taken to provide strength to the bones.
  5. Surgery

COMPLICATIONS

  1. Loss of hearing in adult life (common in type I and Type II)
  2. Heart failure (in Type II)
  3. Respiratory problems
  4. Permanent deformity

AYURVEDIC ASPECT OF OSTEOGENESIS IMPERFECTA

Osteogenesis imperfecta or brittle bone disease in Ayurveda can be correlated to Sahaja Vyadhis that means the genetic disorders. Acharyas believe that the abnormalities in the bones that are Asthi kshaya and Majja kshaya (depletion of bone marrow) are caused mainly due to vitiation of Vata Dosha.

Lakshanas (symptoms) of Asthi Kshaya can be

  1. Hair Fall from scalp or beard
  2. Brittle nails
  3. Weakness and fatigue
  4. Loosening of joints

Lakshanas (symptoms) of Majja Kshaya can be

  1. Degeneration of bones
  2. Weakness

CHIKITSA (TREATMENT)

There is not any specific treatment for treating this disease, only management of the disease can be done to avoid any further complications. This can be done by treating or pacifying the aggravated Vata Dosha and management of the condition can be done accordingly.

HERBAL REMEDIES BY PLANET AYURVEDA FOR OSTEOGENESIS IMPERFECTA

Planet Ayurveda is a GMP certified brand that manufactures herbal supplements. Planet Ayurveda is dedicated to bring the benefits of natural herbs to mankind through some completely natural herbal products that cures diseases without causing any ill effect to the patient.The products manufactured by Planet Ayurveda has no added preservatives or any adulterants.This company exports their products worldwide like to the USA, Europe, Africa and many other countries.  All the products by Planet Ayurveda are manufactured following the ancient Ayurvedic texts under the guidance and supervision of experts of Ayurveda. They have plenty of medicines for various diseases both chronic and acute. Listed are few medicines that improve conditions and manages the symptoms caused by Osteogenesis imperfecta

Product List

  1. Lakshadi Guggul
  2. Bone Support Capsules
  3. Cissus Power Capsules
  4. Boswellia Curcumin
  5. Gandhak Rasayan
  6. Arjun Ghrit

Description of the products that manages Osteogenesis imperfecta well

1) Lakshadi Guggul Tablets

Lakshadi Guggul in the form of tablets by planet Ayurveda shows effective results in  Osteogenesis imperfecta by maintaining both bone and muscle health. Lakshadi guggul consists of Laksha (Laccifer lacca), Arjuna (Terminalia Arjuna), Ashwagandha (Withania somnifera), shuddh Guggul (purified Commiphora mukul) and a lot other herbal drugs that enhances calcium deposition to the bones that even fastens healing a fractured bone too. This product also helps in other conditions like osteoporosis by improving bone density.

Dosage – 1-2 tablets twice or thrice daily with lukewarm water.

2) Bone Support Capsules

These capsules by Planet Ayurveda work well for maintenance of a healthy skeletal system. These capsules consist of the Goodness of  Hadjod (Cissus quadrangularis), Mukta (compound of pearl), Praval pishti (Corallium rubrum) and various other drugs. These ingredients improve the mineral density of bones and make it a better absorbent of calcium. They also strengthen the connective tissues of the bone that prevents it from breaking.

Dosage – 1 capsule twice a day, with plain water after meals.

3) Cissus Power Capsules

These capsules by Planet Ayurveda are made of Hadjod (Cissus quadrangularis) which are rich in vitamin C and help in mineralization and formation of the bones by increasing the strength and density of the bones. These capsules also reduce inflammation and pain in joints. It supports growth of cells and also regeneration of it by preventing loss of bone tissue.

Dosage – 1-2 Capsules twice a day with plain water after meals.

4) Boswellia Curcumin

Boswellia Curcumin Capsules by Planet Ayurveda consist of Shallaki (Boswellia serrata) which is a herb that treats bone diseases by preventing excessive wear and tear of joints. It reduces pain and inflammation of the joints too. Another content of this formulation is Curcumin (Curcuma longa) that helps in building and repairing of the bones.

Dosage –  1 capsule twice a day with plain water after meals.

5) Gandhak Rasayan

These Gandhak Rasayan Capsules are made of extraction of a single component Gandhak better known as Sulphur. Sulphur or Gandhaka helps to treat weak and fractured bones, it helps to make glucosamine and collagen that plays a vital role in maintaining healthy bones and joints. It also protects the cell from damage.

Dosage – 1-2 tablets twice or thrice a day with lukewarm water.

6) Arjun Ghrit

This classical preparation of Arjun Ghrit is mentioned in the classics of Ayurveda. It has Arjuna (Terminalia arjuna), Amalaki (Emblica officinalis), Nagarmotha (Cyperus rotundus) and various other herbs along with Ghee. Arjuna is considered to have bone regeneration properties that help to make healthy bones. All these ingredients also help in improving bone density hence better strength to bones.

Dosage – ½ teaspoon twice a day with warm water or milk.

Contact Planet Ayurveda Support Team to provide you with the costing/ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 842-749-4030.

CONCLUSION

Here we can conclude that Osteogenesis imperfecta (OI) or brittle bone disease is a genetic disorder of the bone caused due to some abnormality in the gene mutation. This condition can not be reversed and babies who are born with it need to survive with it forever, however certain measures for the management of the disease both by Ayurveda and Modern Science are explained above. Ayurveda considers this condition among the Sahaja Rogas to be genetic disorders and all the symptoms are same as that caused due to aggravation of Vata Dosha so the management is done accordingly. Hence this condition needs to be managed to avoid further complications.

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November 2, 2023

Osteogenesis Imperfecta Treatment In Ayurveda

Osteogenesis Imperfecta (OI)

Abstract

Osteogenesis imperfecta (OI), additionally acknowledged as brittle bone disease, is an uncommon genetic ailment depicted with the aid of impaired bone electricity and elevated susceptibility to fractures.This abstract offers an overview of OI, which include its genetic basis, scientific manifestations, diagnosis, and management.OI is particularly brought about by way of mutations in the genes accountable for producing kind I collagen, a key issue of bone matrix.

These mutations end in peculiar collagen production, mainly to bone fragility and different connective tissue abnormalities. The severity of OI can fluctuate widely, ranging from moderate varieties with few fractures to extreme varieties with severe fractures and good-sized skeletal deformities.

Osteogenesis Imperfecta (OI)

From Frailty to Fortitude: Introducing Osteogenesis Imperfecta

The title “osteogenesis imperfecta” actually describes imperfect bone formation. The circumstance used to be first described in the scientific literature in the late seventeenth century with the aid of Danish health practitioner Lorenz G. N. Beck. Since then, our grasp of OI has drastically developed through developments in genetics, diagnostic techniques, and remedy strategies. OI is particularly precipitated with the aid of mutations in the genes accountable for producing kind I collagen, the most plentiful protein in bone. These mutations can disrupt the production, structure, or feature of collagen, ensuing in weakened bones. Collagen performs a fundamental function in supplying energy and guidance to bones, as nicely as in the formation of different connective tissues in the body.

Ayurveda’s Ancient Wisdom for Osteogenesis Imperfecta

Ayurveda, the standard gadget of remedy in India, processes fitness and ailment from a holistic perspective, focusing on balancing the body, mind, and spirit. While Ayurveda no longer especially points out Osteogenesis imperfecta, it gives insights into aiding bone fitness and standard well-being. According to Ayurveda, bone fitness is influenced by the stability of the Vata, Pitta, and Kapha doshas, which are the three indispensable energies or concepts in the body. In the case of Osteogenesis imperfecta, an Ayurvedic cure would be intended to tackle imbalances in these doshas and aid bone electricity and healing.

Dosha

Vata is related to the air and area factors and governs motion and conversation in the body. Osteogenesis imperfecta can be viewed as a Vata imbalance, as the bones are fragile and inclined to fractures.

Ayurvedic remedies for balancing Vata might also contain heat oil massages, mild bodily therapies, and a nourishing weight-reduction plan to promote steadiness and strength.

Pitta Dosha

Pitta represents the furnace and water factors and is accountable for metabolic approaches in the body.

In the context of Osteogenesis imperfecta, Pitta dosha may additionally be worried about helping bone recovery and stopping inflammation. Cooling and soothing therapies, alongside a Pitta-pacifying diet, can be encouraged to limit irritation and assist bone health.

Kapha Dosha

Kapha is related to the earth and water factors and governs shape and balance in the body. Balancing Kapha can be helpful for bone fitness as it offers fundamental electricity and support.

Ayurvedic cures to stability Kapha may also contain invigorating exercises, dry massages, and a food plan that promotes metabolism and prevents immoderate accumulation of fluids.

Causes

Here are the main causes of osteogenesis imperfecta

Genetic Mutations

Osteogenesis imperfecta is notably triggered via mutations in genes that affect the production, structure, or niche of the kind I collagen, which is the ample structure of collagen located in bones. Mutations in the COL1A1 and COL1A2 genes, which furnish guidelines for producing collagen, are the most frequent genetic motives of OI.

Inheritance

Osteogenesis imperfecta is typically inherited in an autosomal dominant pattern, which means a character solely wants to inherit one replica of the mutated gene from one affected father or mother to strengthen the condition. In some uncommon cases, it can be inherited in an autosomal recessive pattern, which requires each mother and father to lift a replica of the mutated gene.

Spontaneous Mutations

In about 35% of cases, the genetic mutations inflicting osteogenesis imperfecta happen spontaneously, except for any household records of the condition. These spontaneous mutations can manifest in the course of the formation of reproductive cells or early in fetal development.

Collagen Structure and Production

Collagen is a fundamental aspect of bone tissue and presents energy and flexibility. Mutations in the genes that are accountable for collagen manufacturing can lead to the manufacturing of ordinary or decreased quantities of collagen, affecting the structural integrity of bones.

Collagen Quality

Even if the manufacturing of collagen is normal, mutations can affect the pleasure of collagen molecules, making them much less steady and greater susceptible to breakage. This leads to fragile bones and different connective tissue issues related to OI.

Fragility Unmasked: The Struggles of Osteogenesis Imperfecta

Here Are Some Common Symptoms Associated With OI

Frequent Bone Fractures

The hallmark symptom of OI is expanded susceptibility to bone fractures. Fractures might also take place with minimal or no obvious trauma and can manifest at some point in hobbies and things to do such as crawling, walking, or even turning in bed.

Fractures may also be current at the start or happen at some stage in childhood and adulthood.

Brittle Bones

Bones in folks with OI tend to be vulnerable and brittle, mainly to deformities, brief stature, and skeletal abnormalities. The bones may also be abnormally shaped, have a decreased density, and be inclined to deformities such as bowing of the lengthy bones or curvature of the backbone (scoliosis).

Bone Pain

OI can cause continual bone pain, which may also range in depth relying on the severity of the circumstance and the presence of fractures or deformities.

Loose Joints and Hypermobility

Joint laxity and hypermobility (greater than an everyday variety of joint motion) are frequent in persons with OI. This can make joints unstable and make the chance of dislocations bigger.

Blue or Gray Sclera

The whites of the eyes (sclera) might also have a blue or grayish tint, which is triggered using the translucency of the collagen-poor connective tissues in the eye.

Dental Problems

OI can affect the improvement and shape of teeth, mainly to dental abnormalities such as brittle teeth, enamel defects, and a greater threat of cavities.

Hearing Loss

Some types of OI are related to listening to loss. The listening impairment can vary from moderate to extreme and may also be existing at the beginning or boost later in life.

Respiratory Problems

In extreme instances of OI, the weak spot of the chest wall and bizarre bone shape can lead to respiratory difficulties and an expanded danger of respiratory infections.

Easy Bruising and Skin Fragility

The pores and skin may additionally be fragile and susceptible to bruising in folks with OI. Cuts and wounds might also heal slowly and depart scars.

Unleashing Resilience: Diagnosing Osteogenesis Imperfecta, Unlocking Strength

Diagnosing osteogenesis imperfecta generally entails an aggregate of medical evaluation, household records assessment, imaging studies, and genetic testing.

Here are some steps generally taken in the diagnostic process.

Medical Records and Bodily Examination

The health practitioner will evaluate the patient’s scientific history, consisting of any preceding fractures or bone-related symptoms. They will operate a thorough bodily examination, searching for symptoms of skeletal deformities, brief stature, and different related features.

Family History

OI is a genetic disorder, and household records of widely widespread fractures or recognized instances of OI can assist guide the diagnosis. The physician may also ask about fractures or bone abnormalities in shut relatives.

Imaging Studies

X-rays are often used to consider the bones and perceive fractures or bone deformities. X-rays can exhibit thinning of the bones, fractures in some levels of healing, and attribute bone abnormalities related to OI.

Bone Density Measurement

Dual-energy X-ray absorptiometry (DXA) scan, normally used to check bone density in osteoporosis, may additionally be carried out to consider bone mineral density in humans suspected of having OI.

Genetic Testing

OI is prompted with the aid of mutations in genes accountable for collagen production or structure, such as the COL1A1 and COL1A2 genes.

Genetic testing, generally via a blood sample, can perceive these mutations and verify the analysis of OI. This step can additionally assist in deciding the particular kind of OI and its inheritance pattern.

Rebuild, Restore, and Rejuvenate with Herbal Remedies by Planet Ayurveda

Planet Ayurveda is a GMP certified company manufacturing totally ayurvedic products without causing any kind of adverse effects to the body. These products are prepared using standardized extract and by following Ancient ayurveda principles. For Osteogenesis imperfecta we have various products out of which some of them are listed below.

Products List

  1. Lakshadi Guggul
  2. Bone Support
  3. Boswellia Curcumin
  4. Arjuna Capsules
  5. Cissus Powder
  6. Gandhak Rasayan

Herbal Remedies for Osteogenesis ImperfectaBuy Now: Herbal Remedies for Osteogenesis Imperfecta

Products Description

1. Lakshadi Guggul

This pill carries the following herbs i.e Guggul (Commiphora Mukul), Laksha (Laccifer lacca), Hadjod (Cissus quadrangularis), Arjuna (Terminalia arjuna). It helps to reduce fractures, reinforce bones, relieve aches, and ideal deposition of calcium in the body.

Dosage: 2 tabs twice daily twice daily

2. Bone Support

This tablet includes the following herbs: Purified laksha (Laccifer lacca), Suhanjana beej (Moringa oliefera), Arjuna (Terminalia Arjuna) etc. It is prosperous in calcium. It is fantastic for making bones strong. It is additionally wealthy -in calcium and is necessary for bone strengthening. It helps to keep bone density, heals fractured bones, and beautifies the deposition of calcium.

Dosage: One capsule twice a day

3. Boswellia Curcumin

It is a product of Planet Ayurveda and is a want for the cure of inflammatory and painful conditions. The elements are stuffed with the goodness of two herbs, particularly shallaki (Boswellia serrata) and (Curcuma longa). Both herbs are stated to have analgesic, wound healing, antimicrobial, antipyretic, and anti-inflammatory properties. With these homes, Boswellia Curcumin helps in struggling with the infection furnish and assists in all the associated signs and symptoms and signs and symptoms that occur due to Osteogenesis.

Dosage: One capsule twice a day

4. Arjuna Capsules

This tablet is fashioned from the bark extracts of Terminalia arjuna. It is noticeably fantastic in curing many disorders. It has anti-bacterial, anti-fungal, anti-viral, anti-inflammatory, hypercholesterolaemic, anti-oxidizing, and hypolipidemic characteristics.

Dosage: One capsule twice a day

5. Cissus Powder

This Powder utilizing Planet Ayurveda is a single natural formula organized by the use of the standardized extract of hadjod (Cissus quadrangularis). As its title indicates, it assists in becoming a member of Bones.Hadjod is additionally recognized by its several names i.e. Nalleru, Mogaroli, kandvel and Hadsankal. It is a quadrangular herb having quadrangular branches, a Quadrangular stem, and largely ovate leaves with 3-7 lobes. It has a candy taste, mild and dry properties, and a warm potency. Hadjod is a vata and kapha pacifier and helps healthful locomotion.

Dosage: One capsule twice a day

6. Gandhak Rasayan

This classical herbal preparation is prepared using gandhak (Purified Sulphur). It helps to aid healthy skin and acts as an amazing rasayan as per Ayurveda. Gandhak rasayan is an amazing formulation which works well in all kinds of skin infections.

Dosage- 2 tabs twice daily

Home Remedies and Lifestyle Modification Tips

While there is no remedy for osteogenesis imperfecta (OI) and scientific administration is essential, there are some domestic treatments and lifestyle adjustments that can assist enhance the fineness of existence for men and women with OI.

It’s vital to be aware that these hints ought to be mentioned to a healthcare expert to make certain they are gorgeous for the unique situation. Here are some tips

Physical Remedy and Mild Exercises

Physical remedies can assist enhance muscle strength, coordination, and joint stability. A bodily therapist can supply workouts and methods tailor-made to the individual’s wants and limitations.

These workouts are typically low-impact and focal points on preserving flexibility, enhancing posture, and improving standard bodily function.

Assistive Devices

Depending on the severity of the condition, assistive gadgets such as braces, splints, or crutches may additionally be endorsed to grant assistance and steadiness to the bones and joints. These gadgets can help stop fractures and enhance mobility.

Fall Prevention Measures

Reducing the danger of falls is imperative for folks with OI. It entails editing the residing surroundings by doing away with tripping hazards, the usage of non-slip mats, and putting in handrails or grasp bars in terrific areas.

It’s additionally fundamental to enhance techniques to shield in opposition to falls, such as getting to know how to fall safely and training in applicable physique mechanics.

Nutrition and bone health

A well-balanced weight loss plan wealthy in calcium, nutrition D, and different necessary vitamins are essential for preserving bone health.

Foods such as milk, yogurt, cheese, leafy greens, fish, and fortified cereals can contribute to ample calcium and nutrition D intake. However, it is really helpful to seek advice from a healthcare expert or registered dietitian to make a certain splendid food plan plan.

Avoidance of Tobacco and Alcohol

Smoking and immoderate alcohol consumption can negatively ect bone health. Individuals with OI need to keep away from smoking and restrict their alcohol consumption to promote higher bone electricity and limit the chance of fractures.

Emotional and Social Support

Living with OI can create challenges, and it is essential to have a sturdy assist machine in place.

Joining guide agencies or connecting with others who have OI can supply emotional support, share experiences, and provide treasured recommendations for coping with the condition.

Regular Scientific Follow-Up

Individuals with OI require normal clinical follow-up to display their bone health, manipulate any complications, and regulate cure plans as needed.

It’s essential to remain in contact with healthcare authorities who specialize in OI to make certain the highest quality care.

Contact Planet Ayurveda Support Team to provide you the costing/ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 842-749-4030

Conclusion

Osteogenesis imperfecta (OI) is a genetic sickness characterized by using fragile bones that damage easily. While there is no cure, clinical management, which includes medications, surgeries, and bodily therapy, can enhance bone fitness and pleasant life. Lifestyle adjustments such as fall prevention, suited nutrition, and social assistance are additionally important. With splendid care and support, humans with OI can lead gratifying lives notwithstanding the challenges posed by way of the condition. Whereas the Ayurvedic drug remedies derived from nature are great in management. There are no aspect outcomes and all the homes of tablets that are required to obtain health are available in the sorts of herbs that nature has furnished us with.

Visit www.planetaurveda.com

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