Author: Dr. Vikram Chauhan

Research Shows That 97% of Herniated Discs Do Not Require Surgery? How Ayurveda Can Help

Abstract

Back pain and pain radiating into the leg are among the most common musculoskeletal complaints affecting adults. A frequent structural finding behind these symptoms is herniation of an intervertebral disc, in which disc material extends beyond its normal boundary and can irritate or compress an adjacent spinal nerve. The diagnosis can sound alarming, and the presence of an abnormality on MRI is sometimes interpreted as an automatic indication for surgery. The available evidence tells a more nuanced story: most patients with uncomplicated lumbar disc herniation improve with non-surgical care, and disc material can undergo spontaneous regression over time. A meta-analysis found spontaneous resorption in approximately 70.4% of conservatively treated lumbar disc herniations overall, with higher rates in extruded and sequestered discs. Another systematic review reported regression rates of 96% for sequestration and 70% for extrusion. Current spine recommendations emphasize that, in the absence of cauda equina syndrome, significant motor weakness, or other serious neurological deficits, conservative treatment should generally be the first-line approach. Surgery becomes important when urgent neurological indications exist or when disabling symptoms persist despite an appropriate course of non-surgical management. In this article, we shall discuss this herniated disc in detail, why many patients recover without surgery, when surgery becomes necessary, and how Ayurveda can be incorporated into a structured approach to pain, stiffness, mobility, and functional recovery.

Herniated Discs Do Not Require Surgery?

Introduction

An intervertebral disc is a specialized structure positioned between adjacent vertebrae. It acts as a shock absorber and allows the spine to move while distributing mechanical loads. Each disc has an outer fibrous ring called the annulus fibrosus and an inner gel-like nucleus pulposus. Repeated loading, age-related degeneration, sudden strain, poor lifting technique, trauma, or a combination of these factors can weaken the annulus. Disc material can then protrude or escape beyond its usual anatomical boundary. When the displaced material contacts an adjacent nerve root, symptoms such as radiating pain, numbness, tingling, and weakness can develop. The lumbar spine is particularly susceptible because it bears substantial mechanical load. Lumbar disc herniation is therefore one of the most common structural causes of sciatica, particularly at the L4-L5 and L5-S1 levels. An important point for patients is that an MRI abnormality and a surgical emergency are not the same thing. Imaging tells us what the spine looks like; the clinical examination tells us what the lesion is doing.

What Exactly Is a Herniated Disc?

A herniated disc develops when part of the nucleus pulposus moves through a weakened or torn annulus fibrosus. Disc pathology is commonly described using terms such as:

Disc Bulge

The disc extends beyond its normal margins over a broad area. A bulging disc does not necessarily represent a focal herniation.

Protrusion

A focal disc herniation in which the base of the displaced material is broader than the portion extending beyond the disc margin.

Extrusion

The displaced disc material extends beyond the disc space and has a narrower connection with the remaining disc material.

Sequestration

A fragment becomes separated from the main disc and can migrate within the spinal canal. These distinctions are clinically relevant because larger, extruded, and sequestered herniations demonstrate greater rates of spontaneous regression than simple bulges.

Why Does a Herniated Disc Cause Pain?

Pain is not caused purely by the physical size of a disc abnormality. Two mechanisms are particularly important:

Mechanical Nerve Compression

A herniated fragment can narrow the space around a spinal nerve root. This can produce:

  • Leg pain
  • Numbness
  • Tingling
  • Weakness
  • Altered reflexes

Inflammation

The nucleus pulposus contains inflammatory substances that can provoke an inflammatory reaction around the affected nerve root. Consequently, a relatively modest amount of compression can sometimes produce substantial pain. This is one reason why symptoms do not always correspond directly to the size of the MRI finding.

Why Do So Many Herniated Discs Improve Without Surgery?

A herniated disc is not necessarily a permanent mass that remains unchanged forever. The body can gradually reduce and resorb displaced disc material. A systematic review found spontaneous regression in:

  • 96% of sequestrated discs
  • 70% of extruded discs
  • 41% of protruded discs
  • 13% of bulging discs

A subsequent meta-analysis involving more than 2,200 conservatively treated patients found an overall spontaneous resorption rate of approximately 70.4%, with resorption occurring more frequently in ruptured discs than contained disc abnormalities. Another systematic review and meta-analysis found a pooled regression rate of approximately 63% after non-surgical treatment.

Causes of Herniated Disc

A herniated disc usually results from a combination of disc degeneration and mechanical stress.

Age-Related Degeneration : Discs gradually lose water and elasticity with age. The annulus becomes more vulnerable to fissures and tears.

Improper Lifting : Repeatedly lifting heavy objects, especially with bending and twisting, increases spinal loading.

Sudden Trauma : A fall, accident, sports injury, or forceful movement can precipitate acute herniation.

Repetitive Mechanical Stress : Occupations involving:

  • Heavy lifting
  • Repeated bending
  • Rotational movements
  • Prolonged vibration

can increase spinal stress.

Poor Physical Conditioning : Weak trunk musculature and reduced physical fitness can make the spine less capable of handling repeated loads.

Excess Body Weight : Increased mechanical loading can place additional stress on the lumbar spine.

Smoking : Smoking is associated with disc degeneration and impaired tissue health.

Risk Factors

Important risk factors include:

  • Increasing age
  • Occupations involving lifting
  • Repetitive spinal loading
  • Obesity
  • Smoking
  • Sedentary lifestyle
  • Poor core strength
  • Previous disc disease
  • Family susceptibility
  • Recurrent spinal strain

Signs and Symptoms

Symptoms depend upon the location and severity of the herniation.

Low Back Pain : Pain may be localized to the lumbar region.

Sciatica : When a lumbar nerve root is irritated, pain can travel from the lower back into the buttock and down the leg.

Numbness : Patients can experience reduced sensation along the distribution of the affected nerve.

Tingling : A pins-and-needles sensation can occur.

Muscle Weakness : Significant nerve compression can produce weakness in:

  • Foot dorsiflexion
  • Toe extension
  • Plantar flexion
  • Knee extension

depending on the affected nerve root.

Movement-Related Pain : Pain can intensify during:

  • Coughing
  • Sneezing
  • Bending
  • Lifting
  • Prolonged sitting

Red Flag Symptoms: When Surgery Cannot Be Delayed

The fact that many patients recover conservatively should never encourage someone with neurological red flags to postpone medical treatment.

Cauda Equina Syndrome : Urgent medical attention is required when a patient develops:

  • New bladder dysfunction
  • Urinary retention or loss of bladder control
  • Bowel dysfunction
  • Saddle-area numbness
  • Severe or progressive bilateral leg symptoms

A large lumbar disc herniation is one of the common causes of cauda equina syndrome, and it is treated as a surgical emergency.

Progressive Motor Weakness : Increasing weakness of the foot, ankle, knee, or leg requires urgent specialist assessment.

Severe Neurological Deficit : Significant motor impairment changes the treatment pathway and can favor early decompression. Current recommendations specifically identify progressive neurological impairment and severe motor deficits as important indications for surgery.

Investigations

Clinical Examination : A neurological examination evaluates:

  • Muscle strength
  • Reflexes
  • Sensation
  • Gait
  • Straight-leg-raising response
  • Nerve-root distribution

MRI : MRI is the preferred imaging modality when imaging is clinically indicated because it provides detailed information about:

  • Disc morphology
  • Nerve compression
  • Spinal canal narrowing
  • Soft tissues
  • Other structural pathology

Imaging should always be interpreted together with the clinical picture.

X-Ray : Plain radiographs can identify:

  • Vertebral alignment
  • Degenerative changes
  • Spondylolisthesis
  • Structural abnormalities

However, X-rays do not directly visualize the disc and nerve root as effectively as MRI.

Electrodiagnostic Testing : EMG and nerve-conduction studies can be useful when the diagnosis is unclear or when symptoms need to be distinguished from other peripheral nerve disorders.

Contemporary Management: Why Conservative Care Comes First

The World Federation of Neurosurgical Societies Spine Committee recommends conservative management as first-line treatment for lumbar disc herniation when there is no cauda equina syndrome, motor deficit, or other serious neurological deficit. The recommended approach combines appropriate medication, activity modification, and physical therapy.

Stay Active Within Tolerance

Complete prolonged bed rest is generally not the goal. Appropriate activity helps prevent:

  • Muscle deconditioning
  • Stiffness
  • Fear of movement
  • Loss of physical capacity

Activity should be modified according to pain and neurological symptoms.

Physiotherapy

A structured exercise program can focus on:

  • Core stabilization
  • Postural correction
  • Spinal mobility
  • Neural mobilization
  • Gradual strengthening

Evidence reviews identify exercise therapy, patient education, mobilization, and selected rehabilitation strategies as important components of conservative care for lumbar disc herniation with radiculopathy.

Medicines

Depending on individual circumstances, physicians can use:

  • NSAIDs
  • Analgesics
  • Selected neuropathic pain medicines
  • Short-term medications for severe symptoms

Epidural Injections

In selected patients with persistent radicular pain, an epidural steroid injection can be considered.

Surgery

Surgery is not simply an alternative to every MRI-confirmed disc herniation. It becomes particularly relevant when there is:

  • Cauda equina syndrome
  • Progressive neurological deficit
  • Significant motor weakness
  • Persistent disabling radicular pain despite appropriate conservative management

Current recommendations identify failure of conservative treatment, cauda equina syndrome, and progressive neurological impairment among the principal indications for surgery. Surgery generally provides faster symptom relief in appropriately selected patients, although longer-term differences between surgery and non-surgical care can become smaller.

How Long Can Recovery Take?

Recovery varies according to:

  • Disc morphology
  • Degree of nerve irritation
  • Neurological deficit
  • Duration of symptoms
  • Physical condition
  • Treatment adherence

A review published in 2024 reported symptom resolution in approximately 60–80% of patients within 6–12 weeks and 80–90% over the longer term, in the absence of major neurological deficits. Disc regression itself can occur over several months, with substantial resorption occurring during the first six months in the literature reviewed.

Can Ayurveda Treat Herniated Disc?

Ayurveda does not describe MRI-defined disc herniation as a separate anatomical diagnosis. However, the most appropriate single Ayurvedic correlation for lumbar disc herniation presenting with radiating leg pain, stiffness, restricted movement, and nerve-related symptoms is Vataja Gridhrasi. Gridhrasi is characterized by pain that follows the pathway of the lower limb and can include stiffness, pricking sensations, and difficulty in movement. The presentation therefore provides a useful Ayurvedic framework for the clinical symptom complex of lumbar radiculopathy. Ayurvedic pathology can be understood as a Vata-dominant disorder affecting the Snayu (ligaments), Kandara (tendons), Asthi and Majja-related structures of the lower back and lower limb.

Excessive physical exertion, improper posture, lifting, repetitive strain, irregular lifestyle, inadequate nourishment, and depletion of tissues aggravate Vata Dosha. Aggravated Vata enters the vulnerable lumbar and lower-limb structures, disturbing normal movement and producing Shoola (pain), Stambha (stiffness), Toda (piercing pain), Supti (numbness), and restricted movement. When the Vata disturbance follows the pathway of the sciatic nerve, the presentation corresponds closely with Vataja Gridhrasi.

The Ayurvedic pathogenesis can therefore be represented as:

Vata Prakopa → localization in Kati-Pradesha and associated Snayu/Kandara → obstruction and dysfunction of normal movement → Gridhrasi-like radicular pain → stiffness, sensory disturbance and impaired mobility.

Ayurvedic Management

Ayurvedic management focuses on Vata Shamana (pacification of Vata dosha), Srotoshodhana (channel cleansing), pain reduction, restoration of mobility, and strengthening of the musculoskeletal system. Internal formulations are selected according to the patient’s constitution and symptom pattern, while external therapies such as Abhyanga (medicated massage), Swedana (fomentation), Kati Basti (ayurvedic therapy), Patra Pinda Sweda  (ayurvedic therapy), Pizhichil  (ayurvedic therapy), and appropriately planned Basti (enema) therapy can form part of a physician-supervised protocol. Gentle physiotherapy and progressive strengthening are integrated as symptoms settle. Dietary measures focus on warm, nourishing, easily digestible meals and avoidance of excessive fasting, highly irregular eating patterns, and activities that aggravate pain. The overall Ayurvedic strategy is to calm Vata, improve functional mobility, reduce pain and stiffness, strengthen supporting tissues, and facilitate a gradual return to normal activity.

Ayurvedic Therapies Commonly Used in a Herniated-Disc Program

Depending on the patient’s condition, an Ayurvedic physician can select therapies such as:

Abhyanga

Warm medicated oil massage is used to pacify Vata, relax muscles, and promote comfortable movement.

Swedana

Controlled herbal fomentation provides warmth and relaxation to stiff musculature.

Kati Basti

Warm medicated oil is retained over the lower back within a localized herbal-dough enclosure. It is frequently incorporated into Ayurvedic programs for lumbar pain and stiffness.

Patra Pinda Sweda

Herbal leaf boluses provided localized warmth and massage to painful or stiff regions.

Basti

Appropriately selected Basti therapy has an important place in Ayurvedic Vata management and is planned according to individual strength, disease stage, digestion, and medical suitability. These procedures should be performed by trained Ayurvedic professionals after assessment rather than self-administered.

Dietary Guidance

Food does not physically “push” a herniated disc back into place, but a healthy dietary routine contributes to recovery by supporting body weight, digestion, nutritional status, and overall physical health.

Prefer

  • Warm freshly prepared meals
  • Adequate protein
  • Whole grains
  • Cooked vegetables
  • Pulses according to digestive tolerance
  • Nuts and seeds
  • Adequate hydration
  • Moderate healthy fats

Reduce

  • Repeated overeating
  • Highly processed foods
  • Excessive alcohol
  • Smoking
  • Very irregular meal patterns

Exercise During Recovery

Exercise should be progressive rather than aggressive.

During the painful phase, focus on:

  • Short walks
  • Comfortable positional changes
  • Gentle mobility
  • Therapist-guided exercises

As symptoms improve, progress toward:

  • Core strengthening
  • Glute strengthening
  • Hip mobility
  • Back stabilization
  • Functional training

Evidence supports exercise as an important component of conservative treatment for lumbar disc herniation and associated radicular symptoms.

Herbal Remedies for Herniated Disc by Planet Ayurveda

Planet Ayurveda is a globally recognized Ayurvedic healthcare company dedicated to promoting natural wellness through authentic herbal formulations. The company combines the wisdom of Ayurveda with modern manufacturing standards to develop products prepared from carefully selected herbs. Its wide range of capsules, tablets, powders, syrups, oils, and specialized herbal combinations addresses various aspects of health and well-being. Planet Ayurveda emphasizes purity and quality, offering formulations free from unnecessary synthetic additives. Planet Ayurveda is pleased to present its Disc Care Pack for an Ayurvedic approach to herniated disc and associated back and nerve discomfort.

Product list

  1. Boswellia Curcumin
  2. Yograj Guggul
  3. Hakam Churna
  4. Aamvatantak Churna
  5. Mahatriphala Ghrit

Herbal Remedies for Herniated Disc

Buy Now Herbal Remedies for Herniated Disc

Buy Now Herbal Remedies for Herniated Disc

Product description

1. Boswellia Curcumin Capsules

Planet Ayurveda’s Boswellia Curcumin contains two focused herbal ingredients: Shallaki (Boswellia serrata) and Curcumin (Curcuma longa), listed at 250 mg each per capsule. Shallaki supplies boswellic acids associated with modulation of inflammatory pathways, while curcuminoids from Haridra provide antioxidant and inflammation-modulating activity. Their combination is particularly suited to maintaining comfortable movement and supporting muscles, joints, tendons, and other musculoskeletal structures.

Dosage: 2 capsules twice daily after meals with warm water.

2. Yograj Guggul

Yograj Guggul is a classical multi-herbal formulation centered on Shuddha Guggulu (Commiphora mukul). It contains Chitraka (Plumbago zeylanica), Pippali (Piper longum), Haritaki (Terminalia chebula), Amalaki (Emblica officinalis), Mustaka, Ardraka (Zingiber officinale), and other digestive and Vata-balancing ingredients. Guggulu is the principal Vata-pacifying component, while the digestive herbs support Agni (digestion) and help maintain efficient metabolism. The formulation therefore aimed at reducing stiffness, supporting mobility, and maintaining healthy musculoskeletal function.

Dosage: 2 tablets twice daily after meals with warm water.

3. Hakam Churna

Hakam Churna is a product of Planet Ayurveda and is a four-herb combination containing Chandershoor (Lepidium sativum), Kalaunji (Nigella sativa), Methi (Trigonella foenum-graecum), and Ajwain (Trachyspermum ammi). The combination is a Tridoshic Rasayana supporting healthy digestion and general body functions. These ingredients provide an important digestive component. Ayurveda places considerable emphasis on maintaining healthy Agni (digestive), particularly when managing Vata-related disorders. Better digestive balance complements the broader musculoskeletal regimen and supports a healthy metabolic environment. It also acts as an analgesic and relieves tingling sensation. It pacifies vata dosha, which makes hakam Churna an effective remedy for Herniated disc.

Dosage: 1 teaspoon twice daily with warm water after meals.

4. Aamvatantak Churna

Aamvatantak Churna contains Ashwagandha (Withania somnifera), Methi (Trigonella foenum-graecum), Suranjaan (Colchicum autumnale), Gorakhmundi (Sphaeranthus indicus), Haridra (Curcuma longa), and Sonth (Zingiber officinale). The formulation helps maintain joint health and manage Ama-related blockages. Ashwagandha contributes strengthening and restorative support, Haridra provides curcuminoids with antioxidant and inflammation-modulating properties, while Sonth and Methi support digestive metabolism. Suranjaan is an important classical ingredient used in Ayurvedic joint formulations. The combination fits the Ayurvedic approach of addressing Ama and Vata while promoting comfortable movement and healthier joint and musculoskeletal function.

Dosage: 1 teaspoon twice daily with warm water after meals.

5. Mahatriphala Ghrit

Mahatriphala Ghrit is a ghrita-based Ayurvedic formulation containing Triphala—Amalaki (Emblica officianlis), Bibhitaki (Terminalis bellirica), and Haritaki (Terminalia chebula), along with Bhringraj (Eclipta alba), Vasa (Adhatoda vasica), Shatavari (Asparagus racemosus), Giloy (Tinospora cordifolia), Mulethi (Glycyrrhiza glabra), Nilofer (Nymphaea alba), and other ingredients, prepared with cow’s ghee and goat milk. The unctuous nature of Ghrita helps in Vata aggravation management, while Triphala supports digestion and regular elimination. Shatavari and the other nourishing herbs add a restorative dimension to the formulation. Mahatriphala Ghrit has a Vata-anulomana role and helps in the management of pain associated with herniated-disc care.

Dosage: 1 teaspoon twice daily with warm water after meals.

Conclusion

A diagnosis of herniated disc does not automatically mean that an operation is required. The available evidence demonstrates substantial spontaneous regression of lumbar disc herniations, particularly extruded and sequestered discs, and modern spine recommendations place conservative treatment first when there is no cauda equina syndrome, serious neurological deficit, or progressive motor weakness. The frequently quoted 97% figure should not be presented as a universal medical statistic. A more accurate and clinically useful conclusion is that the majority of uncomplicated lumbar disc herniation cases can initially be managed without surgery, while a smaller but important group requires urgent or elective surgical intervention based on neurological findings and the response to conservative treatment. Surgery also remains valuable because it can provide faster relief for appropriately selected patients. Ayurveda offers a structured framework for these non-operative cases by correlating the pain-radiation pattern with Vataja Gridhrasi and addressing Vata aggravation, stiffness, pain, impaired movement, tissue support, digestion, and functional recovery. A combination of appropriate internal formulations, Ayurvedic therapies, postural correction, physiotherapy, gradual strengthening, and lifestyle regulation creates a comprehensive approach. Planet Ayurveda’s Disc Care Pack brings musculoskeletal comfort, Vata balance, mobility, and overall functional support. The strongest approach to herniated disc is neither “surgery for everyone” nor “surgery for nobody.” It is an individualized pathway in which neurological safety comes first, conservative care is given an appropriate opportunity when suitable, and Ayurveda and rehabilitation are used strategically to support pain control, mobility, strength, and return to normal life.

Upadacitinib: The JAK1 Switch Turning Down Inflammation In Rheumatoid Arthritis

Abstract

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterised by persistent synovial inflammation, pain, swelling, stiffness, progressive joint damage, and functional impairment. Although conventional and biologic disease-modifying antirheumatic drugs (DMARDs) have transformed RA management, some patients continue to experience inadequate disease control or intolerance to existing therapies. Upadacitinib is an orally administered, selective Janus kinase 1 (JAK1) inhibitor that targets intracellular signalling pathways involved in the production and activity of multiple inflammatory cytokines. By reducing JAK1-dependent signalling, it can suppress inflammatory activity and improve clinical manifestations of RA. Clinical trials have demonstrated improvements in disease activity, physical function, pain, morning stiffness, and remission rates, including in patients with inadequate responses to conventional synthetic or biologic DMARDs. Long-term studies have continued to demonstrate sustained efficacy, although careful monitoring for infections, herpes zoster, laboratory abnormalities, thrombosis, malignancy, and cardiovascular events remains essential. This article reviews the mechanism, therapeutic role, clinical evidence, safety considerations, and potential Ayurvedic interpretation of upadacitinib in rheumatoid arthritis.

Upadacitinib

Introduction

Rheumatoid arthritis is an immune-mediated inflammatory disorder in which dysregulated immune responses primarily affect the synovial joints. Persistent inflammation can cause synovial hypertrophy, cartilage destruction, bone erosion, deformity, and loss of physical function. The disease may also involve organs beyond the musculoskeletal system, making RA a systemic condition rather than simply a disorder of the joints. Modern treatment aims to achieve remission or sustained low disease activity through early and appropriately targeted DMARD therapy. Methotrexate remains a major component of initial treatment, while biologic DMARDs and targeted synthetic DMARDs are used when disease activity remains inadequately controlled. Upadacitinib has emerged as an important targeted synthetic DMARD. Unlike biologic medicines that generally act outside the cell by binding specific inflammatory mediators or their receptors, upadacitinib works inside immune cells by inhibiting JAK1-mediated signalling. This intracellular mechanism allows it to influence several cytokine pathways simultaneously.

Understanding the JAK-STAT Pathway

The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway is an important communication system used by numerous cytokine receptors. When a cytokine binds to its receptor, associated JAK proteins become activated and phosphorylate STAT proteins. STATs then enter the nucleus and regulate gene expression involved in immune activation, inflammation, cell survival, and differentiation. JAK1 participates in signalling from several cytokines relevant to inflammatory diseases. Excessive or persistent cytokine signalling contributes to the inflammatory environment characteristic of RA. Therefore, interfering with this pathway provides a mechanism for reducing downstream inflammatory activity. Upadacitinib is designed to preferentially inhibit JAK1. The term “JAK1 switch” in the title is therefore a useful metaphor: rather than literally switching inflammation off, the drug reduces an important intracellular signalling route that helps maintain inflammatory responses.

How Upadacitinib Works in Rheumatoid Arthritis

Upadacitinib is a selective JAK1 inhibitor administered orally. By inhibiting JAK1, it decreases signalling through cytokine pathways dependent on JAK1 activity. This can reduce the expression and activity of inflammatory mediators involved in synovitis and systemic inflammation. The therapeutic consequence is not limited to one inflammatory molecule. Instead, modification of intracellular signalling can influence several cytokine-driven processes at once. This helps explain why clinical improvements may be observed across multiple domains of RA, including tender and swollen joints, pain, morning stiffness, physical function, and overall disease activity. Importantly, JAK signalling also contributes to normal immune defence and hematopoietic processes. Consequently, therapeutic inhibition can produce adverse effects as well as anti-inflammatory benefits. This dual nature makes appropriate patient selection and monitoring particularly important.

Therapeutic Role in Rheumatoid Arthritis

Upadacitinib may be used in adults with moderately to severely active RA when conventional treatment has not provided sufficient control or has not been tolerated, according to applicable regulatory indications. Treatment decisions should be individualised according to previous DMARD exposure, disease severity, comorbidities, infection risk, cardiovascular risk, and patient preferences. Clinical guidelines emphasise a treat-to-target strategy in RA, in which therapy is adjusted according to disease activity rather than simply continued indefinitely without reassessment. European Alliance of Associations for Rheumatology (EULAR) recommendations recognise JAK inhibitors, including upadacitinib, as targeted synthetic DMARDs but emphasise careful assessment of cardiovascular, malignancy, and thromboembolic risk when considering their use.

Safety Profile, Tolerability, and Monitoring

As a potent immunomodulatory agent, the therapeutic benefits of Upadacitinib must be balanced against its potential risk profile. Selective JAK1 inhibition alters immune surveillance mechanisms, requiring structured baseline screening and ongoing clinical monitoring.

Infectious Risks

The primary adverse events associated with Upadacitinib stem from immune suppression. Upper respiratory tract infections, urinary tract infections, and bronchitis are among the most frequently observed. Notably, JAK inhibitors as a class carry an increased risk for Herpes Zoster reactivation (shingles), likely due to the suppression of type I and type II interferon signalling essential for antiviral defence. Prior vaccination against Herpes Zoster is highly recommended before initiating treatment.

Thrombotic Risk

Clinical surveillance of the JAK inhibitor class has highlighted a potential increase in the incidence of Venous Thromboembolism (VTE), including deep vein thrombosis and pulmonary embolism. Risk factors such as advanced age, cardiovascular history, smoking, and baseline hypercoagulability require careful screening prior to prescribing Upadacitinib.

Laboratory Monitoring

Upadacitinib administration can cause transient or sustained alterations in biochemical and haematological parameters. Regular laboratory testing is recommended to monitor:

    • Haematology: Neutropenia, lymphopenia, and mild decreases in haemoglobin levels.
    • Lipid Profiles: Dose-dependent increases in total cholesterol, high-density lipoprotein (HDL), and low-density lipoprotein (LDL) cholesterol, typically managed with standard lipid-lowering therapy without compromising cardiovascular risk benefit.
    • Hepatic Transaminases: Transient elevations in alanine aminotransferase (ALT) and aspartate aminotransferase (ALT), particularly when co-administered with hepatotoxic drugs like Methotrexate.
    • Creatine Kinase: Mild elevations in serum creatine kinase without accompanying clinical myopathy.

Ayurveda Insight

While modern biomedicine targets molecular entities like JAK1 enzymes and cytokines, traditional systems of medicine explain chronic autoimmune inflammation through holistic physiological models. In Ayurveda, Rheumatoid Arthritis finds its closest clinical parallel in the disease entity known as Amavata.

The Concept of Amavata and Pathogenesis (Samprapti)

In Ayurvedic physiology, health is maintained by a state of equilibrium among the three doshas (Vata, Pitta, and Kapha), alongside a functional digestive and metabolic fire (Agni). Amavata develops through a dual pathological process:

Agni Mandya (Impaired Metabolic Fire)

Poor digestive capability leads to the incomplete digestion of food in the gastrointestinal tract, generating an endotoxic, sticky, systemic byproduct called Ama.

Vata Prakopa (Aggravation of Vata)

Factors such as a sedentary lifestyle, incompatible diet, physical overexertion, or emotional stress severely aggravate Vata dosha—the primary energy governing biological movement, circulation, and signal transmission.

The aggravated Vata acts as a transport vehicle, carrying the toxic, circulating Ama (toxins) throughout the body’s channels (Srotas) and lodging it within the synovial joints (Sleshma Sthana). Once Ama combines with Kapha and Pitta in the joints, it generates intense local inflammation, heat, swelling, severe stiffness, and structural deformity—a picture identical to the clinical presentation of Rheumatoid Arthritis.

Herbal Remedies as an Alternative to Upadacitinib by Planet Ayurveda

Planet Ayurveda is a wellness brand dedicated to promoting health through the traditional principles of Ayurveda and natural herbs. It offers a wide range of Ayurvedic formulations made with carefully selected herbs and natural ingredients. The brand focuses on supporting various aspects of health, including digestion, immunity, liver, joints, heart, and women’s wellness. Planet Ayurveda combines classical Ayurvedic knowledge with modern quality and manufacturing practices. Its products are designed to provide convenient herbal support for modern lifestyles. The brand promotes a holistic approach that considers nutrition, lifestyle, and overall well-being. Planet Ayurveda aims to make traditional Ayurvedic wellness accessible to people seeking natural healthcare solutions. Here we will discuss some formulations that can be used as a better alternative to Upadacitinib.

  1. Boswellia-Curcumin
  2. Aamvatantak Churna
  3. Ashwagandha Capsules
  4. Joint Aid Plus
  5. RumoGin 5 Capsules
  6. Yograj Guggul

Herbal Remedies of Upadacitinib

Buy Now Herbal Remedies of Upadacitinib

Buy Now Herbal Remedies of Upadacitinib

Product Description

1. Boswellia-Curcumin

Boswellia-Curcumin, containing Shallaki and Curcumin, provides Ayurvedic herbal support for inflammatory joint symptoms associated with rheumatoid arthritis. Boswellia is traditionally valued for supporting healthy inflammatory responses and comfortable joint movement, while curcumin contributes antioxidant and inflammation-modulating activity. Their combined action supports joint comfort, flexibility, and physical mobility in individuals experiencing stiffness and inflammatory discomfort. The formulation also supports protection against oxidative stress affecting musculoskeletal tissues. From an Ayurvedic perspective, these ingredients are used to support balanced Vata and Ama, concepts associated with stiffness, pain, and impaired joint function. This makes Boswellia-Curcumin a supportive component of an integrative approach to inflammatory joint health.

Dosage: 2 capsules twice daily with warm water, after meals.

2. Aamvatantak Churna

Aamvatantak Churna, containing Ashwagandha (Withania somnifera), Methi (Trigonella foenum-graecum), Suranjan (Colchicum luteum), Gorakhmundi (Sphaeranthus indicus), Haridra (Curcuma longa), and Sonth (Zingiber officinale), is formulated to support inflammatory joint and musculoskeletal symptoms associated with Amavata. Ashwagandha supports strength and tissue nourishment, while Haridra and Sonth provide antioxidant and inflammation-modulating properties. Methi contributes nutritional and metabolic support, while Suranjan and Gorakhmundi are traditionally used in Ayurvedic joint-care formulations. The combination supports comfortable movement, joint flexibility, and reduction of stiffness associated with inflammatory conditions. Its Deepana-Pachana action is traditionally used to support digestion and metabolic processing of Ama. Thus, Aamvatantak Churna provides a multi-herbal approach to maintaining joint function and musculoskeletal comfort.

Dosage: 1 teaspoonful twice daily with warm water, before meals.

3. Ashwagandha Capsules

Ashwagandha Capsules, containing Withania somnifera, provide supportive care for individuals experiencing weakness, fatigue, and reduced physical resilience alongside chronic inflammatory joint symptoms. Ashwagandha is traditionally classified as a Rasayana and Balya herb, supporting strength, endurance, and healthy muscle function. Its bioactive constituents, particularly withanolides, have demonstrated antioxidant and inflammation-modulating activity in experimental research. These properties support overall musculoskeletal resilience when chronic joint symptoms interfere with physical activity. Ashwagandha also supports stress adaptation and general well-being, which are relevant during prolonged inflammatory illness. In Ayurveda, its Vata-shamaka properties are associated with maintaining healthy movement and tissue strength.

Dosage: 2 capsules twice daily with warm water, after meals.

4. Joint Aid Plus

Joint Aid Plus, containing Nirgundi (Vitex negundo), Shallaki (Boswellia serrata), Guggul (Commiphora mukul), Sonth (Zingiber officinale), and Ashwagandha (Withania somnifera), provides comprehensive herbal support for joint stiffness, discomfort, and restricted mobility. Nirgundi and Shallaki are traditionally used in Ayurvedic joint-care practices for supporting comfortable movement and balanced inflammatory responses. Guggul contributes traditional support for healthy metabolism and joint function, while Sonth provides warming digestive and musculoskeletal support. Ashwagandha complements the formulation by supporting muscle strength and physical resilience. Together, these ingredients promote joint flexibility and comfort during routine movement. From an Ayurvedic perspective, the combination supports Vata balance and healthy functioning of the musculoskeletal tissues.

Dosage: 2 capsules twice daily with warm water, after meals.

5. RumoGin 5 Capsules

RumoGin 5 Capsules, containing Haridra (Curcuma longa), Sonth (Zingiber officinale), Shallaki (Boswellia serrata), Maricha (Piper nigrum), and Pippali (Piper longum), provides multi-herbal support for inflammatory joint discomfort and stiffness. Haridra and Shallaki contribute antioxidant and inflammation-modulating properties, while Sonth supports digestion and comfortable musculoskeletal function. Maricha and Pippali are traditionally valued for Deepana-Pachana activity and are also used to support the bioavailability and utilisation of other herbal ingredients. The combination is therefore directed toward joint comfort, mobility, and healthy inflammatory balance. In Ayurvedic terms, these herbs support management of Ama-Vata–associated stiffness and discomfort. RumoGin 5 consequently provides targeted herbal support for maintaining comfortable movement in inflammatory joint conditions.

Dosage: 1 capsule twice daily with warm water, after meals.

6. Yograj Guggul

Yograj Guggul, containing Commiphora mukul, Cyperus rotundus, Plumbago zeylanica, Emblica officinalis, Terminalia bellirica, Terminalia chebula, and several other Ayurvedic ingredients, is traditionally used for disorders involving Vata-associated musculoskeletal discomfort and stiffness. Guggul supports healthy inflammatory balance and joint function, while Plumbago and the digestive herbs contribute Deepana-Pachana activity. Haritaki, Bibhitaki, and Amalaki provide antioxidant and tissue-supportive properties. The formulation is traditionally valued for supporting flexibility and comfortable movement when stiffness affects the joints and muscles. Its broader Ayurvedic action focuses on balancing aggravated Vata and supporting the proper metabolism of Ama (toxins). Yograj Guggul therefore serves as a traditional supportive formulation for maintaining musculoskeletal function and joint comfort.

Dosage: 2 tablets twice daily with warm water, after meals.

Conclusion

Upadacitinib represents an important advancement in the treatment of rheumatoid arthritis by selectively targeting JAK1-dependent intracellular signalling. By reducing multiple cytokine-mediated inflammatory pathways, it can improve joint symptoms, physical function, patient-reported outcomes, and disease activity in patients with active RA, including those who have responded inadequately to other DMARDs. Clinical evidence demonstrates that these benefits can persist over several years. At the same time, JAK1 inhibition modifies immune pathways that are important for normal host defence, making safety screening and ongoing monitoring essential. Serious infections, herpes zoster, cardiovascular events, thrombosis, malignancy, and laboratory abnormalities must be considered during treatment. Upadacitinib should therefore be viewed not simply as an “inflammation switch,” but as a powerful targeted DMARD whose benefits depend on appropriate patient selection and responsible monitoring. From an Ayurvedic viewpoint, RA can be explored through the framework of Amavata and Vata-Ama interaction, but this traditional model should complement rather than replace evidence-based rheumatological management.