Severe Combined Immunodeficiency (SCID)
Abstract
Primary immunodeficiency” means that it is a disease caused by the genetics of the immune system. Combined immunodeficiency syndromes are a group of different diseases caused by disturbances in the growth and function of T (Cellular immunity) and B (humoral immunity) cells, which may also include natural killer cells. When the immune system combination causes premature death (usually in the first year of life) from a serious infection, it is said to be “severe.” SCID can be arranged as typical SCID or on the other hand, assuming less serious, flawed SCID in light of the seriousness of cellular cell qualitative and quantitative lack. We will discuss pathogenesis, causes, symptoms, diagnosis, and treatment according to allopathy, Ayurvedic overview of SCID Oja doshas, ojahksaya, and Herbal remedies offered by Planet Ayurveda.
Introduction
It is an uncommon condition made by hereditary transformations that leads to modification in capability and improvement of immune cells. Babies with serious joined immunodeficiency look healthy at the hour of birth yet are very vulnerable to serious contaminations. This is a lethal condition until or except if babies get treatment for immune restoration like enzyme therapy and gene therapy.
Pathogenesis
SCID is a disease brought about by changes in a few qualities whose parts are significant for the turn of events and capability of T and B cells and can influence normal executioner cells. Now and again, sub-atomic deformities inactivate Immune system microorganisms, while B cells are significant. Despite this, Lymphocyte brokenness seriously obstructs compelling resistance since B cells need signals from Immune system microorganisms to create antibodies.
Causes
It is caused by
- ADA (Adenosine deaminase) deficiency.
- CD3 chains deficiency
- Reticular dysgenesis
- Omenn syndrome
- Purine nucleoside phosphorylase deficiency
- Bare lymphocyte syndrome
- Genetic mutations
- Janus Kinase 3 deficiency
Symptoms
Symptoms associated with SCID are as follows
- weakness
- lump
- growth retardation
- difficulty climbing
- diarrhoea
- pneumonia
- respiratory disease
- growth retardation
- thrush
- sinus infection
- ear infection
Diagnosis
- Newborn screening test
- DNA test for genetic mutation
- A full blood lymphocyte count
Treatment
- Gene therapy
- Chemotherapy
- Bone marrow transplant
Prevention
You can diminish the gamble of disease in your child by taking the following preventive measures:
- Staying away from public spots
- Prevent the child from disease or cold
- Restricting guests
- Clean up appropriately before contacting the newborn child.
Ayurvedic Overview
In Ayurveda, we can associate this disease with anuvanshik vyadhi (genetic disease) and other ojahksaya (weak immune system). Anuvanshik vyadhi is formed at birth due to beej dosha (malformation of sperm and egg) deformity. Oja means to prevent disease or to prevent disease in two ways: one is to reduce the disease that occurs, and the other is to prevent the occurrence of the disease. The main factors that contribute to oja (immunity) are three principal doshas, balanced dhatu state, normal agni, the patency of srotas etc. It is what supports the state of all physiological parameters. Ojas is the essence of rasadhi dhatus, also known as Bala (strength).
Ojovaha Srotodusti Lakshana/ Trayo Ojodosha
त्रयो दोषा बलस्योक्ता व्यापद्वि स्रंसनक्षयाः । (सु.सू १५ /३०)
There are three kinds of ojodosha.
- Ojo Visramsa- Displacement from its natural place.
- Ojo Vyapat- Ojas get vitiated by dosha and dusya.
- Ojahksaya- Decrease in its quantity.
Hetu (Etiological Factors) of Oja Kshaya
अभिघातात् क्षयात् कोपाच्छोकाद्धयानाच्छ्र मात् क्षुधः
ओजः सड्.क्षीयते ह्योभ्यो धातु ग्रहणनिः सृतम्।
तेजः समीरितं तस्माद्विस्त्रंसयति देहिनः ।। (सु.सू १५ /२८)
Trauma or injury, tissue depletion (dhatuksaya), anger, sadness, anxiety, fatigue, hunger, etc. For reasons Ojas decreases, causing dhatus to flow out and affect tejas, and provoked by Vata, causing many disturbances in the body.
Clinical Features of Ojahksaya
मूर्च्छा मांसक्षयो मोह: प्रलापोऽज्ञानमेव च ।
पूर्वोक्तानि च लिङ्गानी मरणं च बलक्षये ।। (सु.सू १५ /३२)
- Fainting
- Depletion of muscles
- Unconsciousness
- Delirium
- Improper perception of knowledge
- Death
Prognosis of Oja and Bala Abnormalities
तत्र विस्त्रंसे व्यापन्ने च क्रियाविशेषैरविरुद्धैैर्बलमाप्याययेत् ।
इतरं तु मूढसंज्ञं वर्जयेत् ।। (सु.सू १५ /३३ )
Ojo visramsa and vyapat can be treated by taking drugs that are not different. Ojaksaya is an incurable disease as it is caused by improper understanding.
Planet Ayurveda Offers Herbal Remedies For SCID
Planet Ayurveda produces herbal products following ancient Ayurveda. All of our herbal remedies are made from natural herbs and age-tested formulas. We offer useful natural supplements for general health. Our herbal products are widely used in herbal medicine, herbal powder, herbal tea, herbal medicine, herbal oil, herbal juice, beauty and cosmetics etc. including various. In this disease, no specific treatment is available till now. Only supportive treatment will be given which can delay the progression of the disease and provide some immunity to fight against other infections. Planet Ayurveda provides herbal remedies for severe combined immunodeficiency which are the following
Products List
- Telomere Boostup
- Immune Booster
- Amalaki Rasayan
- Ashwagandha Capsule
- Shilajit Capsules
- Gandhak Rasayan
Product Description
1. Telomere Boostup
This polyherbal capsule is made up of Ashwagandha (Withania somnifera), Moringa (Commiphora wightii), Giloy (Tinospora cordifolia) etc. Its taste is bitter, sweet, and astringent. It is dry and hot in potency. It has a tonic effect on the brain and the nervous system. It acts as an anti-inflammatory, analgesic, diuretic and mildly sedative. It is an immune-modulator, antioxidant and hormone precursor which tends to regulate important physiological functions. It improves general alertness, prevents all types of weakness and increases strength and stamina. It also allays stubborn and recurring infections of the urinary tract. It keeps the heart healthy and prevents free radical damage. It induces sound sleep and reduces inflammation.
Dosage: 1 Capsule two times a day.
2. Immune Booster
This polyherbal capsule is made up of Bhumi amla (Phyllanthus niruri), Amalaki (Emblica officinalis) etc. Its taste is sweet and bitter. It is light and has a cold potency. It strengthens immunity and helps prevent daily wear and tear on the body. It is used to treat fever, anemia, and urinary and reproductive system problems. It also acts as a support for all physiological diseases of the body. It has hepatoprotective properties. So, it is used in the treatment of liver diseases. It contains antioxidants that destroy all bacteria in the body, remove toxins from the body and prevent diseases by reducing the amount of stomach acid. It is suitable for peptic ulcer, indigestion, cough, sore throat, vomiting, hyperacidity, anemia and many other diseases. It can also reduce the firmness of the skin and restore the urinary tract. It keeps the heart healthy and prevents free radical damage.
Dosage: 2 Capsules two times a day.
3. Amalaki Rasayan
It is a herbal medicine that is made up of Amalaki (Emblica officinalis). It has a cold potency. Its taste is sometimes sweet, bitter and pungent. It is dry and has a cold potency. It acts as an antipyretic, diuretic, antacid, and haemostatic. Suitable for nosebleeds, dysfunctional uterine bleeding, leukorrhea, menopausal syndrome, general weight loss, hair and eye problems, jaundice, oedema, cough and asthma. It also helps heal ulcers. It is a good antioxidant and supplement for many chronic diseases.
Dosage: 1 Capsule two times a day.
4. Ashwagandha Capsule
It is a herbal capsule that includes only one herb Ashwagandha (Withania somnifera). It has a hot potency and its taste is bitter and sweet. It helps increase muscle strength, enhances immunity, and supports good heart health. It is used as anti-stress medicine. It is useful in psychiatric disorders, lower backache, insomnia and in high blood pressure. It prevents weakness and improves general alertness as it is a good tonic for the brain. It helps increase body strength.
Dosage: 2 Capsules two times a day.
5. Shilajit Capsules
This single herbal capsule is made up of Shilajit (asphaltum). It has anti-inflammatory, antitumor activity, antioxidant, and anti-asthma properties. It improves digestive problems and improves memory. It regulates blood sugar in the body. It is good for kidney, heart and liver diseases. It increases haemoglobin in the body.
Dosage: 1 Capsule two times a day.
6. Gandhak Rasayan
This herbal tablet is made from Shuddha gandhak (purified sulphur). It is an anti-bacterial, anti-microbial, anti-allergic, antipyretic, anti-viral, broad-spectrum antibiotic. It kills intestinal bacteria and is a good blood purifier. It contains many antioxidants. It is an anti-inflammatory and is indicated for pregnancy, impotence, indigestion, shortness of breath and stomach pain. It detoxifies the blood, removes dirt and prevents secondary infections. It is very important in urinary tract infections as well as in removing harmful bacteria from the body.
Dosage: 2 Tablets two times a day.
Contact Planet Ayurveda Support Team to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or Call at 0172-521-4040 (India), +91-172-521-4040 (Outside India) or Whatsapp at (+91) 9915-593-604
Conclusion
Severe combined immunodeficiency virus is a rare disease characterized by genetic mutations that cause changes in the immune system and development. In Ayurveda, we can associate this disease with anuvanshik vyadhi (genetic disease) and another disease is oja kshaya (weak immune system). There is no specific treatment for this disease, but supportive care can slow the progression of the disease. For the best results, never miss your dose and follow your diet.
