Author: Dr. Vikram Chauhan

March 15, 2023

Hypokalemic Periodic Paralysis Treatment By Herbal Remedies

ABSTRACT

Hypokalemic periodic paralysis is a genetic condition that is associated with muscle weakness and paralysis. Genetic condition comes into context when someone inherits an altered gene from their parents and there is an increase in developing that particular condition too in them. Genes are the proteins in the body that play an important role in transferring any kind of information in the body that is needed to control the body’s growth, development and functioning. So if there is a defect in any of the genes then the definite thing is to develop any condition in the body. Many conditions run into the families and one of them is Hypokalemic Periodic Paralysis. Now we are going to discuss in this article about this condition in detail and the management of this particular condition with the help of ayurvedic remedies.

Hypokalemic Periodic Paralysis

INTRODUCTION

Hypokalemic periodic paralysis, a condition associated with low levels of potassium and includes episodes of severe muscle weakness that generally begins in childhood or at the adolescent age. Mostly these episodes include temporary inability in moving muscles of the arms and legs. There are several attacks almost every day. Particularly this condition occurs rarely but is considered as very severe in nature. Although the exact prevalence of this condition is unknown, hypokalemic periodic paralysis has an estimate to affect 1 in 100,000 people. Men are more prone to experience the symptoms of Hypokalemic periodic paralysis than women. To know more let’s study the causes and symptoms of Hypokalemic periodic paralysis.

CAUSES

It is one of the genetic disorders in which there is a mutation in the gene named CACNA1S and SCN4A. These are the essential genes that provide command for making proteins which play an important role in the skeletal muscles for maintaining their functions. The normal movement of the body is conducted by contraction and relaxation of the skeletal muscles in a coordinated way. The contraction of the muscles are activated by flow of some positively charged ions in the muscle cells. Both the previously mentioned genes form channels which control the flow of that positively charged ions. The CACNA1S transports the calcium ions and the channels of SCN4A helps in transporting the sodium ions. If the mutation occurs in both the genes they alter the functioning and structure of sodium and calcium channels. Thus causes alteration in the contraction of the skeletal muscles which alters the movement of the muscles and leads to the severe muscle weakness and paralysis in episodic periods which is known as hypokalemic periodic paralysis.

SYMPTOMS

As it is a genetic disorder the one who suffered from this condition may experience the symptoms at the age of 10-14 years. The periods occur randomly and get more triggered by some factors like exercise, food items etc. After waking from sling time sleep it’s very habitual to experience. The severity of the attacks vary from forbearing muscle weakness to remarkable paralysis. The episodes may last between several hours to several days and their frequency also varies from human to human. Some of the humans may experience the episodes daily and some may experience a few times a year. With the growing age the episodes of paralysis become fewer and are known as abortive attacks which refers to general weakness that lasts for a longer period of time. Beside all this one may experience the following symptoms:

  • Weakness in muscles
  • Cramping in muscles
  • Heart palpitations
  • Most oftenly the muscles involved are shoulders, arms, legs and hips
  • Paralysis

DIAGNOSIS

This condition is even hard to diagnose as there is not such specific test for this condition. Also we cannot diagnose this condition with the symptoms rather the attack will occur. So if any of you may experience the significant symptoms of Hypokalemic periodic paralysis then it’s a must to visit the physician nearby. The physician will ask you your symptoms, at which time you may experience the symptoms and after that the diagnosis may be clear but it’s difficult to diagnose. If someone have family history then the diagnosis is more clear and at the time of diagnosis if someone experience symptoms then the following diagnostic techniques may be done to clarify the diagnosis:

  • Blood tests for potassium levels
  • Examination of muscle reflexes if they are reduced
  • Electrocardiography if a patient may experience any symptoms related to heart

So above mentioned are some of the diagnostic steps that a physician may perform to diagnose Hyperkalemic periodic paralysis.

AYURVEDIC VIEW

As we read earlier the condition is hereditary and there is a mutation in the genes named CACNA1S and SCN4A. As per ayurveda the hereditary condition is correlated to beej dushti, so let’s discuss what beej dushti is? Beej dushti is the defect in beejbhaga that is the sperm and ovum. Ashuddha shukra (defected sperm) and ashuddha artava (defected ovum) are the main causes of beej dushti. If there is any defect in the gametes (sperm and ovum) of parents then the child should inherit the disease. If we see on the side of dosha pacification then there is the vitiation of vata dosha as it is responsible for any movement and functioning control in the body. Hypokalemic Periodic Paralysis is a genetic condition so we should not cure it but will manage the symptoms of this condition with certain herbal remedies and improve the quality of the patient.

HERBAL REMEDIES BY PLANET AYURVEDA FOR MANAGING HYPOKALEMIC PERIODIC PARALYSIS

Planet Ayurveda is a GMP certified clinic which formulates various herbal supplements for maintaining the overall health as well as alleviating any kind of health issue. The formulations produced by Planet Ayurveda are produced under the strict observance of M.D. Ayurveda practitioners. All the herbal supplements are free from any kind of preservatives, additives, fillers, color, starch, resins and other synthetic material. For the purpose of managing the symptoms of Hypokalemic Periodic Paralysis Planet Ayurveda provides 7 herbal remedies that we will discuss further in detail.

  1. RASARAJESHWAR RAS
  2. ASHWAGANDHAGHAN VATI
  3. MUSLI STRENGTH CAPSULES
  4. GANDHAK RASAYAN
  5. AMRIT KALASH
  6. BRAHMA RASAYAN
  7. GREEN ESSENTIALS

PRODUCT DESCRIPTION

1. RASARAJESHWAR RAS

Ras Rajeshwar Ras is an ayurvedic formulation that has been used for maintaining the health of the nervous system. It consists of ingredients like swarna yukta rasraj ras, ashwagandha (Withania somnifera), guggul (Commiphora mukul) and some others. The ingredients of this formulation contain miraculous vata pacifying balya (strengthening) properties. Due to its properties Rasarajeshwar Rasa aids in promoting the normal functioning of the nervous system as well as strengthening the weakened muscles in case of Hypokalemic Periodic Paralysis.

Dosage: 1 tablet twice daily to be chewed.

2. ASHWAGANDHAGHAN VATI

Ashwagandhaghan vati is a formulation by Planet Ayurveda which is available in tablet form. These herbal tablets consist of Ashwagandha herb (Withania somnifera) that is an effective adaptogenic herb in nature. The adaptogenic properties of ashwagandha helps in reducing stress in the body which further prevents the damage at cellular level. So for preventing the damage of muscle cells Ashwagandhaghan vati is useful in the management of Hypokalemic Periodic Paralysis.

Dosage: 2 tablets twice daily with plain water after meals.

3. MUSLI STRENGTH CAPSULES

Musli Strength Capsules by Planet Ayurveda is a herbal remedy which consists of the standardized extract of two herbs that are safed musli (Chlorophytum borivilianum) and gokshura (Tribulus terrestris). The capsules consist of various properties such as antioxidant, adaptogenic, strengthening, immune boosting and rejuvenating. All these properties make these herbal capsules effective in managing the symptoms of Hypokalemic Periodic Paralysis. It strengthens the weak muscles, promotes the functioning of the skeletal muscles, prevents the degeneration of the skeletal muscle cells as well as prevents from the stage of paralysis.

Dosage: 1 capsule twice daily with plain water after meals.            

4. GANDHAK RASAYAN

Gandhak Rasayan is an ayurvedic formulation that is formulated by Planet Ayurveda under the strict observance of M.D. Ayurveda practitioners. It consists of shuddha gandhak (purified sulphur) which has been used since ancient times in the field of ayurveda for managing several disorders. It is a natural immunity booster, so by boosting the immunity levels this remedy assists in alleviating the muscle weakness associated with Hypokalemic Periodic Paralysis.

Dosage: 2 tablets twice daily with plain water after meals.

5. AMRIT KALASH

Amrit kalash is an ayurvedic formulation that is one of the best rasayana (rejuvenators). Rasayana are the ones that are believed to enhance the resistance of the body towards various infections as well as diseases. Rasayana are considered as effective in enhancing the longevity of life by promoting overall health. Amrit kalash promotes nervous health by pacifying vata dosha and helps in promoting the functioning of skeletal muscles. This rasayana formulation alleviates the weakness of muscles by increasing the reduced contraction, so it is quite effective in the management of Hypokalemic Periodic paralysis.

Dosage: 1 tsp twice daily with plain water after meals.  

6. BRAHMA RASAYAN

Brahma Rasayan is one of the best ayurvedic health supplements which is available in lehya (jam) form. Usually this ayurvedic health supplement is used in various nervous disorders and associated conditions such as anxiety, cognition issues, lack of concentration, etc. As in case of hypokalemic periodic paralysis there is the reduction of contraction of skeletal muscles which leads to their weakness and if not treated later on leads to paralysis of skeletal muscles. The consumption of Brahma Rasayan increases the contraction of skeletal muscles which further reduces the weakness in the muscles.

Dosage: 1 tsp twice daily with plain water twice daily.

7. GREEN ESSENTIALS

Green essentials is a herbal remedy formulated by Planet Ayurveda in capsule form under the observance of M.D. Ayurveda practitioners. These capsules are polyherbal and consist of standardized extracts like grape seed (Vitis vinifera), wheat grass (Triticulum aestivum), spirulina (Spirulina platensis) and some others. These capsules are considered as one of the best immunity booster due to mention of ingredients. Also the antioxidant properties present in these capsules prevent the damage of nerve cells and muscle cells which further prevents paralysis of the skeletal muscles.

Dosage: 2 capsules twice daily with plain water after meals.

CONCLUSION

CONTACT PLANET AYURVEDATO PROVIDE YOU THE COSTING / ORDERING AND DELIVERY INFORMATION AT – COSTING.PLANETAYURVEDA@GMAIL.COM OR CALL AT +91-172-5214040

Hypokalemic periodic paralysis, a condition associated with low levels of potassium and includes episodes of severe muscle weakness that generally begins in childhood or at the adolescent age. It is one of the genetic disorders in which there is a mutation in the gene named CACNA1S and SCN4A. In this case a person may experience weakness in muscles, cramping in muscles, heart palpitations, most oftenly the muscles involved are shoulders, arms, legs and hips and at last paralysis. As per ayurveda the hereditary condition is correlated to beej dushti in which there is a defect in beejbhaga that is the sperm and ovum. Don’t worry the condition is manageable with ayurvedic medications and for this purpose Planet Ayurveda provides various herbal remedies that are free from any kind of additives and preservatives. So without worrying you can start taking treatment from Planet Ayurveda and while consuming remedies if you have any query then you can share your query on www.PlanetAyurveda.com

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March 14, 2023

Giant lymph Node Hyperplasia – Causes, Symptoms, Diagnosis & Treatment

Abstract

Giant lymph node hyperplasia is a rare disorder that commonly involves lymph nodes. Lymph nodes are kidney shaped organs of the lymphatic system and immune system. A large number of lymph nodes are linked together throughout the body via lymphatic vessels. There are 2 major sites of the lymphatic system that are B and T cells. A lymph node is enclosed in a fibrous capsule which is made up of cortex (outer) medulla (inner). They are usually important for the proper functioning of the immune system. There are no detoxification functions, hence they get enlarged or inflamed in various types of throat infections to life threatening cancer.

Lymphadenopathy refers to the glands that are enlarged or swollen when lymph nodes become firm and tender. B cells are mainly found in the outer cortex where there is presence of cluster form, T cells are found in the paracortex. B cells are entering the bloodstream and cells are produced in the bone marrow. Lymph nodes are the most liable structures which are usually large at birth but undergo progessive atrophy throughout life. It acts like a defensive barrier which is virtually present in all systemic infections and in neoplastic conditions. In this topic we are going to study in detail about its causes, types and its ayurvedic management.

INTRODUCTION

Giant lymph node hyperplasia is a rare disorder where benign growths are formed in the lymph node tissues, mainly there is overgrowth of the cells in the body’s lymph nodes. It is known as Castleman’s disease, angiofollicular lymph node hyperplasia, Hyaline vascular type, Back pain. This disease is usually found at ⅔ of the chest, along the tracheobronchial tree in the mediastinum or in parts of the neck, pelvis etc. Usually Giant lymph node hyperplasia is asymptomatic or has non specific symptoms such as cough, chest pain, respiratory infections, and back pain which is usually due to tracheobronchial compression. Castleman’s disease causative factors are human herpesvirus (HHV)-8 also known as kaposi sarcoma  which causes degeneration of the inflammatory mediators and interleukin (IL). In castleman’s disease there is overproduction of IL-6 and overexpression of IL-6 that further leads to proliferation of B lymphocytes.

Giant lymph node hyperplasia

FACTS ABOUT CASTLEMAN’S DISEASE

  • It is a group of three immunologic disorders that occur in all individuals of all age groups and has microscopic lymph node appearance.
  • The signs and symptoms are related to the release of cytokines, mainly interleukin 6.
  • About 6600-7700 patients are estimated to suffer from this disease in the United States.
  • People suffering from HIV are at major risk of developing HHV 8 associated with Castleman’s disease.  
  • HHV 8 is affecting males more than females at a high rate.
  • It affects males and females both in equal numbers and there is no known factor.

PATHOLOGY

Variations in the lymph nodes of patients with this disease lead to 4 histological classifications

  • Plasmacytic- increased number of follicles with large germinal centers and plasmacytosis.
  • Hyaline vascular- It is a regressed germinal center, follicular dendritic cell, prominent mantle zones with onion-like appearance.
  • Hypervascular- It is mainly seen in idiopathic multicentric castle disease which includes the germinal center, follicular dendritic cell with onion-like appearance.
  • Mixed- It is usually a combination of hyaline vascular and hypervascular plasmacytic features.

TYPES OF CASTLEMAN’S DISEASE

1. Unicentric Castleman’s disease

This affects single or multiple lymph nodes in one region of the body hence it is known as localized Castleman’s disease. The causes are unclear.

2. Multicentric Castleman’s disease

Here multiple lymph nodes are involved in the body, half of the cases of MCD are involved which is caused by HHV-8 infection mainly in people with HIV infections. It can be related to idiopathic Multicentric disease

  • iMCD associated with POEMS (polyneuropathy, organomegaly, skin changes)
  • iMCD associated with TAFRO (anasarca, renal dysfunction, thrombocytopenia)
  • iMCD, not specified.

CAUSES

The exact cause of Castleman’s is not known but some causes involves-

  • Human herpesvirus type8 (HHV-8)
  • Human immunodeficiency virus (HIV)
  • Inflammation
  • Weak immune system
  • Acquired genetic mutations

SYMPTOMS

Unilateral castleman’s Disease includes

  • Unintentional weight loss
  • Fever
  • Fatigue
  • Anemia
  • Fullness in stomach or chest
  • Swollen lymph nodes in the neck, armpit or groin region.

Multicentric castleman’s disease includes

  • Fever
  • Stomach pain
  • Nerve damage
  • Enlarged liver or spleen
  • Appetite loss
  • Night sweats
  • Vomitings.

DIAGNOSIS

  • Blood test
  • Urine test
  • CT Scan (Computed tomography)
  • MRI
  • PET (positron emission tomography)
  • Lymph node biopsy  

COMPLICATIONS

Unicentric Castleman’s disease usually affects only one lymph node and when that lymph node is removed it usually does well, but in multicentric castleman’s disease it may lead to multiple organ failure and lead to life-threatening infections.

TREATMENT

In unicentric castleman’s disease– The affected lymph node is surgically removed.

In multicentric castleman’s disease- It requires various medications and therapies to control the cell overgrowth.

  • Immunotherapy
  • Chemotherapy
  • Corticosteroids
  • Antiviral drugs

AYURVEDIC MANAGEMENT

In Ayurveda Giant lymph node hyperplasia is due to imbalances of the tridoshas and due to dushti of rasvaha srotas. Rasa Vaha srotas are the channels of the body which are formed by digestion of food in the stomach and intestines, these juices get circulated through the circulatory system which is pumped to the heart and different parts of the body. This further nourishes all the tissues and organs of the body and supports the life process. Rasavahini dhamani carries their nutritive juices to every part of the body. The contamination of rasa transport channels are rasa pradoshaja rogas (contamination of rasa dhatus).If there is blockage and destruction of digestive fire leads to the formation of ama.

Rasavaha srotas

  1. Mula- heart and great vessels
  2. Marga- venous and lymphatic systems
  3. Mukha- arteriole, venous junction in capillaries. Rasa Vaha srotas are the main srotas that supply the whole body and provide poshana to rasa dhatu and rakta dhatu. The dhatus are structural components an increase or decrease in quantity indicates abnormal metabolism and lowering of immunity. This dhatu travels the whole body through dhamanees and nourishes tissue, organs, doshas, malas.

FACTORS CAUSING VITIATION

  • Guru ahara (heavy food)
  • Cold foods
  • Excessive consumption of oily food
  • Excessive thinking (stress)

MANAGEMENT

  • Vamana
  • Virechana
  • Niruha basti
  • Nasal medications
  • Exercise
  • Exposure to light
  • Starvation

HERBS USEFUL FOR GIANT LYMPH NODE HYPERPLASIA

1. TULSI

Tulsi (Ocimum sanctum) reduces the ill effect of radiotherapy which is due to cancer. Tulsi has katu (pungent) and tikta (bitter) taste, katu vipaka, and has ushna veerya. It usually balances vata and kapha dosha. Tulsi has antimicrobial properties, improves digestion and controls repeated hiccups. For itching or any skin disease tulsi paste is helpful, in kidney and bladder stones tulsi plays an important role.

2. HARIDRA

Haridra (Curcuma longa) is a famous herb administered through nose, oral applications. Haridra is helpful in retarding facial hair growth, cures diabetes, urinary tract disorders, due to its ushna veerya, ruksha guna it removes the all blockage present in the blood vessels and makes nutrition easy, it cleanses and detoxifies the rasa dhatu, hence restores the all normal body functions. Haridra has antioxidant properties, eliminating all toxins out of the cell.

3. GILOY

Guduchi (Tinospora cordifolia) is used extensively for the treatment of fever, urinary tract disorders, and cardiac disorders. Giloy has tikta (bitter), kashaya (astringent) taste. It balances tridoshas, so helpful in relieving the burning sensation (it has madhura vipaka and coolant in nature),  improves digestion power and helps in gout arthritis. Giloy has anti-aging and rejuvenating properties.

4. BHUMI AMLA

Bhumi amla (Phyllanthus niruri) is a liver protecting herb so helpful in inflammation of spleen and liver, and jaundice. Bhumiamla has tikta (bitter), madhura (sweet) taste, and has sheetal veerya. Bhumiamla balances vitiated kapha and pitta dosha. Helpful in bleeding disorders, heavy periods, excessive thirst. It has antispasmodic and analgesic properties. Bhumi amla is helpful in kidney stones, venereal disease, hypertension, and gonorrhoea.

HERBAL REMEDIES BY PLANET AYURVEDA FOR GIANT LYMPH NODE HYPERPLASIA

Ayurvedic medicines help to relieve diseases, and maintain a healthy lifestyle without any side effects. Planet ayurveda is a natural brand that is serving humanity. All the medications prepared are free from any preservatives, colors, dye. The formulations made are from planet extract and 100% vegetarian. The medications prepared reduce the risk of recurrence and they are prepared under strict surveillance of the experts team. So many remedies are provided by planet ayurveda for Giant lymph node hyperplasia which we are going to discuss in detail.

Herbal Remedies for Giant lymph node Hyperplasia

Herbal Supplements for Giant lymph Node Hyperplasia

PRODUCTS LIST

  1. TULSI CAPSULES
  2. GILOY CAPSULES
  3. IMMUNE BOOSTER
  4. KANCHNAAR GUGGUL
  5. BOSWELLIA CURCUMIN

PRODUCTS DESCRIPTION

1. Tulsi Capsules

Tulsi capsules are single herbal capsules formulated by planet ayurveda using ingredients Tulsi (Ocimum tenuiflorum). These capsules are beneficial in patients suffering from allergy, diabetes and provide immunity to fight against infections. It usually maintains immunity and ojas, malas (excreta), and body energy. Tulsi capsules are helpful in respiratory disorders, abdominal upsets therefore balance all doshas of the body.

Dosage– 1-2 capsules twice daily with plain water after meals.

2. Giloy Capsules

Giloy Capsules are single herbal capsules formulated by planet ayurveda using ingredients like Giloy (Tinospora cordifolia). Giloy capsules have antipyretic, anti-inflammatory, and are excellent blood purifiers so useful in skin problems, anemia, jaundice, and all types of cancers. This capsule has the ability to kill macrophages and protects the stomach from increasing production of mucin. Giloy capsules are helpful in stomach ulcers, and in condition ITP (idiopathic thrombocytopenic purpura) which further increases blood platelet count.

Dosage– 1-2 capsules twice daily with plain water after meals.

3. Immune Booster

Immune booster are poly herbal capsules formulated by planet ayurveda using ingredients such as Grape seed (Vitis vinifera), Go- Piyush (Bovine colostrums), Amalaki (Emblica officinalis). These capsules throw out the toxins and further cleanses it, protecting from recurrent infections. Immune booster prevents development of particular disease and defends against germs and microorganisms. This capsule has cow colostrums which help in building and provide strength and guard against diseases as it contains minerals, proteins.

Dosage– 1-2 capsules twice daily with plain water after meals.

4. Kanchnaar Guggul

Kanchnaar guggul are herbal tablets formulated by planet Ayurveda using ingredients like Guggul (Commiphora mukul), Kachnaar (Bauhinia variegata). This preparation is helpful in reducing the chance of PCOS so helpful in balancing kapha dosha, improves the function of ovaries. Kachnaar Guggul reduces the fat accumulation so it is helpful in reshaping the body and controls excessive weight, in endometriosis it removes the blockage and controls the movement of vata thus reducing its symptoms.

Dosage– 1-2 tablets twice daily with plain water after meals.

5. Boswellia Curcumin

Boswellia Curcumin are polyherbal capsules formulated by planet ayurveda using ingredients like Shallaki (Boswellia serrata), Curcumin (Curcuma longa). This capsule has an inflammatory effect useful in conditions like cervical spondylitis, chronic colitis, and brain tumors. This capsule has turmeric in it so turmeric has an antioxidant rich formula that has neuroprotective activity and maintains a healthy cardiovascular system.

Dosage– 1 capsule twice daily after meals with plain water.

Contact Planet Ayurveda to provide you the costing / ordering and delivery information at – costing.planetayurveda@gmail.com or call at +91-172-5214040 Or Check Website – www.PlanetAyurveda.com

CONCLUSION

Giant lymph node hyperplasia is a rare disorder that commonly involves lymph nodes. Lymph nodes are kidney shaped organs of the lymphatic system and immune system.  It is known as Castleman’s disease, in Ayurveda Giant lymph node hyperplasia is due to imbalances of the tridoshas and due to dushti of rasvaha srotas. Planet Ayurveda provides many remedies for Giant Lymph Node Hyperplasia which is very effective in this disease without causing any side effects.

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